Technology Process of Ethyl cis/trans-3-methylcyclohexanecarboxylate
There total 12 articles about Ethyl cis/trans-3-methylcyclohexanecarboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 76 percent / aq. NaOH, glycine, NAD, FMN / HLADH / 72 h / 20 - 25 °C / pH 9.0
2: 71 percent / HBr / 15 h / 20 °C
3: (Bu)3SnH / benzene / 20 h, 20 deg C; reflux, 4 h
With
sodium hydroxide; NAD; hydrogen bromide; tri-n-butyl-tin hydride; glycine; Flavin mononucleotide;
HLADH;
In
benzene;
DOI:10.1021/ja00317a046
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 96 percent / 50 percent NaH / tetrahydrofuran; paraffin / 20 h / Heating
2: 67 percent / 1) Cu(I)OAc; 2) 6 N HCl / 24 h / Heating
3: 5 percent NaOH / methanol / 0.75 h / 20 °C
4: toluene-p-sulfonic acid / benzene / 4 h / Heating
5: 95 percent / W-2 Raney Ni / ethanol / 4 h / Heating
6: H2 / 10 percent Pd-C / methanol / 48 h / 20 °C
7: 76 percent / aq. NaOH, glycine, NAD, FMN / HLADH / 72 h / 20 - 25 °C / pH 9.0
8: 71 percent / HBr / 15 h / 20 °C
9: (Bu)3SnH / benzene / 20 h, 20 deg C; reflux, 4 h
With
hydrogenchloride; sodium hydroxide; W-2 Raney Ni; NAD; hydrogen bromide; hydrogen; tri-n-butyl-tin hydride; copper (I) acetate; sodium hydride; toluene-4-sulfonic acid; glycine; Flavin mononucleotide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; ethanol; paraffin; benzene;
DOI:10.1021/ja00317a046
