2-(4-benzyloxy-phenyl)-5-hydroxy-3,6,7-trimethoxy-chromen-4-one

Base Information

• Chemical Name: 2-(4-benzyloxy-phenyl)-5-hydroxy-3,6,7-trimethoxy-chromen-4-one
• CAS No.: 14801-90-2
• Molecular Formula: C₂₅H₂₂O₇
• Molecular Weight: 434.445
• Mol file: 14801-90-2.mol

Synonyms:2-(4-benzyloxy-phenyl)-5-hydroxy-3,6,7-trimethoxy-chromen-4-one

Chemical Property of 2-(4-benzyloxy-phenyl)-5-hydroxy-3,6,7-trimethoxy-chromen-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-benzyloxy-phenyl)-5-hydroxy-3,6,7-trimethoxy-chromen-4-one

There total 5 articles about 2-(4-benzyloxy-phenyl)-5-hydroxy-3,6,7-trimethoxy-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(4-Benzyloxy-phenyl)-3,5,6,7-tetramethoxy-chromen-4-one (14801-88-8) → 2-(4-benzyloxy-phenyl)-5-hydroxy-3,6,7-trimethoxy-chromen-4-one (14801-90-2)

Guidance literature:

With aluminum tri-bromide; In acetonitrile; at 0 - 5 ℃; for 0.333333h;

Reference yield:

1-(2,6-dihydroxy-3,4-dimethoxy-phenyl)-2-methoxy-ethanone (100059-77-6) + 4-benzoyloxy-benzoic acid-anhydride (205652-96-6) → 2-(4-benzyloxy-phenyl)-5-hydroxy-3,6,7-trimethoxy-chromen-4-one (14801-90-2)

Guidance literature:

With sodium-<4-benzoyloxy benzoate>; at 185 ℃; unter vermindertem Druck und anschliessend Behandeln mit wss.-aethanol. Kalilauge;

DOI:10.1016/0040-4020(58)88011-4

Reference yield:

p-(benzyloxy)benzoic acid anhydride (1486-49-3) → 2-(4-benzyloxy-phenyl)-5-hydroxy-3,6,7-trimethoxy-chromen-4-one (14801-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) potassium benzoate, 2.) K₂CO₃ / 1.) 170/180 deg C, 8 h, 2.) acetone, reflux, 2.5-4 h

2: 88 percent / AlBr₃ / acetonitrile / 0.33 h / 0 - 5 °C

With aluminum tri-bromide; Potassium benzoate; potassium carbonate; In acetonitrile;

upstream raw materials:

1-(2,6-dihydroxy-3,4-dimethoxy-phenyl)-2-methoxy-ethanone

4-benzoyloxy-benzoic acid-anhydride

2-(4-Benzyloxy-phenyl)-3,5,6,7-tetramethoxy-chromen-4-one

p-(benzyloxy)benzoic acid anhydride

Downstream raw materials:

Toluene-4-sulfonic acid 2-(4-benzyloxy-phenyl)-3,6,7-trimethoxy-4-oxo-4H-chromen-5-yl ester

Toluene-4-sulfonic acid 2-(4-benzyloxy-phenyl)-3-hydroxy-6,7-dimethoxy-4-oxo-4H-chromen-5-yl ester

2-(4-Benzyloxy-phenyl)-3,5-dihydroxy-6,7-dimethoxy-chromen-4-one

3,5,4'-trihydroxy-6,7-dimethoxy-flavone