8,9,10,11-Tetrahydrodibenzo[A,H]acridine

Base Information

• Chemical Name: 8,9,10,11-Tetrahydrodibenzo[A,H]acridine
• CAS No.: 97135-12-1
• Molecular Formula: C₂₁H₁₇N
• Molecular Weight: 283.373
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40393564
• Wikidata: Q82192366
• Mol file: 97135-12-1.mol

Synonyms:97135-12-1;8,9,10,11-Tetrahydrodibenz(a,h)acridine;8,9,10,11-TETRAHYDRODIBENZO[A,H]ACRIDINE;2-azapentacyclo[12.8.0.03,12.04,9.015,20]docosa-1(14),2,4(9),10,12,15,17,19,21-nonaene;8,9,10,11, Tetrahydrodibenz(a,h)acridine;SCHEMBL5275839;DTXSID40393564;AKOS030240276;FT-0674989;2-azapentacyclo[12.8.0.0?,??.0?,?.0??,??]docosa-1(14),2,4(9),10,12,15,17,19,21-nonaene

Chemical Property of 8,9,10,11-Tetrahydrodibenzo[A,H]acridine

Chemical Property:

• Vapor Pressure: 2.54E-10mmHg at 25°C
• Melting Point: 170 - 171掳C
• Refractive Index: 1.752
• Boiling Point: 518.1°C at 760 mmHg
• Flash Point: 231.5°C
• PSA: 12.89000
• Density: 1.222g/cm³
• LogP: 5.42000
• Storage Temp.: -20?C Freezer
• XLogP3: 6.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 283.136099547
• Heavy Atom Count: 22
• Complexity: 405

Purity/Quality:

97% ^*data from raw suppliers

8,9,10,11-Tetrahydrodibenz(a,h)acridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC2=C(C1)C=CC3=CC4=C(C=CC5=CC=CC=C54)N=C23
• Uses: This compound is an interesting intermediate in the synthesiis of the epoxy-diol derivtives of dibenz(a,h)acridine (Catalogue number D41690) which is the proximate or ultimate carcinogen This compound is an interesting intermediate in the synthesiis of the epoxy-diol derivtives of dibenz(a,h)acridine (Catalogue number D41690) which is the proximate or ultimate carcinogen.

Technology Process of 8,9,10,11-Tetrahydrodibenzo[A,H]acridine

There total 1 articles about 8,9,10,11-Tetrahydrodibenzo[A,H]acridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-amino-5,6,7,8-tetrahydronaphthalene (2217-41-6) + β-naphthol (135-19-3) → 8,9,10,11-tetrahydrodibenzacridine (97135-12-1)

Guidance literature:

Reference yield:

8,9,10,11-tetrahydrodibenzacridine (97135-12-1) → trans-10,11-bis(benzoyloxy)-8,9,10,11-tetrahydrodibenz(a,h)acridine (97135-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 28 h / Heating

2: 65 percent / I₂ / benzene / 15 h / Heating

With iodine; In acetic acid; benzene;

DOI:10.1021/jo00217a011

Reference yield:

8,9,10,11-tetrahydrodibenzacridine (97135-12-1) → (+/-)-trans-10,11-dihydroxy-10,11-dihydrodibenzyacridine (97135-18-7,110927-22-5)

Guidance literature:

Multi-step reaction with 7 steps

1: acetic acid / 28 h / Heating

2: 65 percent / I₂ / benzene / 15 h / Heating

3: 90 percent / 30percent aq. NaOH / tetrahydrofuran; methanol / 2.5 h / Ambient temperature

4: 90 percent / pyridine / 18 h / Ambient temperature

5: 97 percent / N-bromosuccinimide, α,α'-azobis(isobutyrodinitrile) / CCl4 / 0.25 h / 63 - 65 °C

6: 71 percent / Li₂CO₃, LIF, HMPA / 3 h / 85 - 90 °C

7: 70 percent / NH₃ gas, / tetrahydrofuran; methanol / 2.5 h / Ambient temperature

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); ammonia; iodine; lithium carbonate; lithium fluoride; In tetrahydrofuran; methanol; tetrachloromethane; acetic acid; benzene;

DOI:10.1021/jo00217a011

upstream raw materials:

formaldehyd

1-amino-5,6,7,8-tetrahydronaphthalene

β-naphthol

Downstream raw materials:

dibenz[a,h]acridine

8,9-dihydrodibenz(a,h)acridine

11-hydroxy-8,9,10,11-tetrahydrodibenz(a,h)acridine

(+/-)-trans-10,11-dihydroxy-10,11-dihydrodibenzyacridine