methyl (2R)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propanoate

Base Information

• Chemical Name: methyl (2R)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propanoate
• CAS No.: 1332232-74-2
• Molecular Formula: C₁₅H₁₉NO₅
• Molecular Weight: 293.32
• Mol file: 1332232-74-2.mol

Synonyms:methyl (2R)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propanoate

Chemical Property of methyl (2R)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (2R)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propanoate

There total 10 articles about methyl (2R)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (Z)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propenoate (1332232-67-3) → methyl (2R)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propanoate (1332232-74-2)

Guidance literature:

With {Rh[(R,R)-Me-Duphos](COD)}BF₄; hydrogen; In methanol; at 40 ℃; for 16h; under 5171.62 Torr; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/op200129m

Reference yield:

methyl (Z)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propenoate (1332232-67-3) → methyl (2S)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propanoate (1332232-58-2) + methyl (2R)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propanoate (1332232-74-2)

Guidance literature:

With hydrogen; In methanol; at 25 ℃; under 5250.53 Torr; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/op200129m

Reference yield:

4-(hydroxylmethyl)benzaldehyde (52010-97-6) → methyl (2R)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propanoate (1332232-74-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium acetate; acetic anhydride / ethyl acetate / Reflux

2: 5 h / Reflux

3: {Rh[(R,R)-Me-Duphos](COD)}BF₄; hydrogen / methanol / 16 h / 40 °C / 5171.62 Torr

With {Rh[(R,R)-Me-Duphos](COD)}BF₄; hydrogen; sodium acetate; acetic anhydride; In methanol; ethyl acetate; 1: Erlenmeyer-Plochl azlactone and amino acid synthesis;

DOI:10.1021/op200129m

upstream raw materials:

methyl (Z)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propenoate

4-[(Z)-(2-methyl-5-oxo-1,3-oxazol-4(5H)-ylidene)methyl]benzyl acetate

1,4-bis(hydroxymethyl)benzene diacetate

terephthalaldehyde,