methyl (Z)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propenoate

Base Information

• Chemical Name: methyl (Z)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propenoate
• CAS No.: 1332232-67-3
• Molecular Formula: C₁₅H₁₇NO₅
• Molecular Weight: 291.304
• Mol file: 1332232-67-3.mol

Synonyms:methyl (Z)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propenoate

Chemical Property of methyl (Z)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (Z)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propenoate

There total 4 articles about methyl (Z)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

methanol (67-56-1) + 4-[(Z)-(2-methyl-5-oxo-1,3-oxazol-4(5H)-ylidene)methyl]benzyl acetate (930117-83-2) → methyl (Z)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propenoate (1332232-67-3)

Guidance literature:

for 5h; Reflux;

DOI:10.1021/op200129m

Reference yield:

terephthalaldehyde, (623-27-8) → methyl (Z)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propenoate (1332232-67-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / tetrahydrofuran; water / 2.33 h / 30 °C

2: sodium acetate; acetic anhydride / ethyl acetate / Reflux

3: 5 h / Reflux

With sodium tetrahydroborate; sodium acetate; acetic anhydride; In tetrahydrofuran; water; ethyl acetate; 2: Erlenmeyer-Plochl azlactone and amino acid synthesis;

DOI:10.1021/op200129m

Reference yield:

4-(hydroxylmethyl)benzaldehyde (52010-97-6) → methyl (Z)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propenoate (1332232-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate; acetic anhydride / ethyl acetate / Reflux

2: 5 h / Reflux

With sodium acetate; acetic anhydride; In ethyl acetate; 1: Erlenmeyer-Plochl azlactone and amino acid synthesis;

DOI:10.1021/op200129m

upstream raw materials:

methanol

4-[(Z)-(2-methyl-5-oxo-1,3-oxazol-4(5H)-ylidene)methyl]benzyl acetate

1,4-bis(hydroxymethyl)benzene diacetate

terephthalaldehyde,

Downstream raw materials:

methyl (2R)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propanoate

methyl (2S)-2-(acetylamino)-3-[4-(acetoxymethyl)phenyl]propanoate