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128259-63-2

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128259-63-2 Usage

General Description

2-Chloro-7-methoxyquinoline-3-carbonitrile is a chemical compound with the molecular formula C11H7ClN2O. It is a quinoline derivative that is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-CHLORO-7-METHOXYQUINOLINE-3-CARBONITRILE has a chlorine atom at the 2-position and a methoxy group at the 7-position on the quinoline ring, as well as a cyano group at the 3-position. It is commonly utilized in the pharmaceutical industry for the production of various drugs due to its versatile reactivity and structural properties.

Check Digit Verification of cas no

The CAS Registry Mumber 128259-63-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,2,5 and 9 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 128259-63:
(8*1)+(7*2)+(6*8)+(5*2)+(4*5)+(3*9)+(2*6)+(1*3)=142
142 % 10 = 2
So 128259-63-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H7ClN2O/c1-15-9-3-2-7-4-8(6-13)11(12)14-10(7)5-9/h2-5H,1H3

128259-63-2 Well-known Company Product Price

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  • Aldrich

  • (BBO000030)  2-Chloro-7-methoxyquinoline-3-carbonitrile  AldrichCPR

  • 128259-63-2

  • BBO000030-1G

  • 2,255.76CNY

  • Detail

128259-63-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-CHLORO-7-METHOXYQUINOLINE-3-CARBONITRILE

1.2 Other means of identification

Product number -
Other names 3-Quinolinecarbonitrile,2-chloro-7-methoxy

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:128259-63-2 SDS

128259-63-2Relevant articles and documents

lH-Pyrazolo[3,4-b]quinolin-3-amine derivatives inhibit growth of colon cancer cells via apoptosis and sub G1 cell cycle arrest

Karthikeyan, Chandrabose,Amawi, Haneen,Viana, Arabela Guedes,Sanglard, Leticia,Hussein, Noor,Saddler, Maria,Ashby, Charles R.,Moorthy, N.S. Hari Narayana,Trivedi, Piyush,Tiwari, Amit K.

, p. 2244 - 2249 (2018/05/31)

A series of lH-pyrazolo[3,4-b]quinolin-3-amine derivatives were synthesized and evaluated for anticancer efficacy in a panel of ten cancer cell lines, including breast (MDAMB-231 and MCF-7), colon (HCT-116, HCT-15, HT-29 and LOVO), prostate (DU-145 and PC3), brain (LN-229), ovarian (A2780), and human embryonic kidney (HEK293) cells, a non-cancerous cell line. Among the eight derivatives screened, compound QTZ05 had the most potent and selective antitumor efficacy in the four colon cancer cell lines, with IC50 values ranging from 2.3 to 10.2 μM. Furthermore, QTZ05 inhibited colony formation in HCT-116 cells in a concentration-dependent manner. Cell cycle analysis data indicated that QTZ05 caused an arrest in the sub G1 cell cycle in HCT-116 cells. QTZ05 induced apoptosis in HCT-116 cells in a concentration-dependent manner that was characterized by chromatin condensation and increase in the fluorescence of fluorochrome-conjugated Annexin V. The findings from our study suggest that QTZ05 may be a valuable prototype for the development of chemotherapeutics targeting apoptotic pathways in colorectal cancer cells.

Base-catalyzed cyclization reaction of 2-chloroquinoline-3-carbonitriles and guanidine hydrochloride: A rapid synthesis of 2-amino-3H-pyrimido[4,5-b] quinolin-4-ones

Chandra, Atish,Upadhyay, Shraddha,Singh, Bhawana,Sharma, Neha,Singh, Radhey M.

scheme or table, p. 9219 - 9224 (2011/12/01)

t-BuOK-catalyzed cyclization of 2-chloroquinoline-3-carbonitriles with guanidine hydrochloride provided simple and rapid synthesis of 2-amino-3H-pyrimido[4,5-b]quinolin-4-ones in very short reaction time with good yield. Other 1,3-binucleophiles are found to react at the same rate. This methodology could be extended with their 3-formyl and 3-ester derivatives for the synthesis of pyrimido annulated quinolines.

Pyrazolo-fused quinoline analogues: Synthesis of 1H-pyrazolo [3, 4-b] quinolines and 3-amino-1H-pyrazolo [3, 4-b] quinolines from 3-formyl and 3-cyano-2-chloroquinolines

Srivastava, Ambika,Singh, Mrityunjay K.,Singh

, p. 292 - 296 (2007/10/03)

Stepwise synthesis of 1H-pyrazolo [3, 4-b] quinolines 6 has been described from the reactions of 2-chloro-3-formylquinolines 1 with ethyleneglycol and hydrazine hydrate reagents in sequence followed by hydrolysis with BiCl 3. However, 3-amino-1H-pyrazolo[3, 4-b]quinolines 7 have been synthesized from 2-chloro-3-cyanoquinolines 2 with excess of hydrazine hydrate in one step. The functional group manipulation of amino group in compounds 7 has also been studied.

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