Technology Process of 7-chloro-3-methyl-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid dimethylamide
There total 8 articles about 7-chloro-3-methyl-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid dimethylamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
7-chloro-3-methyl-4-oxo-1-phenyl-1,4-dihydro-quinoline-2-carboxylic acid;
With
N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
under 760.051 Torr;
Inert atmosphere;
dimethyl amine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 48h;
under 760.051 Torr;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrahydrofuran / 2 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere
2.1: toluene / 16 h / 110 °C / 760.05 Torr / Inert atmosphere
3.1: potassium carbonate / methanol / 1 h / 80 °C / 760.05 Torr / Inert atmosphere
4.1: sodium hydroxide / 1,4-dioxane / 150 °C / 760.05 Torr / Inert atmosphere; Sealed tube
4.2: 760.05 Torr / Inert atmosphere
5.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C / 760.05 Torr / Inert atmosphere
5.2: 48 h / 20 °C / 760.05 Torr / Inert atmosphere
With
potassium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: toluene / 16 h / 110 °C / 760.05 Torr / Inert atmosphere
2.1: potassium carbonate / methanol / 1 h / 80 °C / 760.05 Torr / Inert atmosphere
3.1: sodium hydroxide / 1,4-dioxane / 150 °C / 760.05 Torr / Inert atmosphere; Sealed tube
3.2: 760.05 Torr / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C / 760.05 Torr / Inert atmosphere
4.2: 48 h / 20 °C / 760.05 Torr / Inert atmosphere
With
potassium carbonate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; sodium hydroxide;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene;
