ethyl 2-(3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-2-oxoindolin-3-yl)acetate

Base Information

Chemical Name:ethyl 2-(3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-2-oxoindolin-3-yl)acetate
CAS No.:1373242-31-9
Molecular Formula:C₃₃H₂₈FNO₆
Molecular Weight:553.587
Hs Code.:

Synonyms:ethyl 2-(3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-2-oxoindolin-3-yl)acetate

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Chemical Property of ethyl 2-(3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-2-oxoindolin-3-yl)acetate

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Technology Process of ethyl 2-(3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-2-oxoindolin-3-yl)acetate

There total 6 articles about ethyl 2-(3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-2-oxoindolin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1373242-30-8
3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)indolin-2-one

: 105-36-2
ethyl bromoacetate

: 1373242-31-9
ethyl 2-(3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-2-oxoindolin-3-yl)acetate

Guidance literature:: 3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)indolin-2-one; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

ethyl bromoacetate; In tetrahydrofuran; at 0 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 1373242-31-9
ethyl 2-(3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-2-oxoindolin-3-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 3 h / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 8 h / 0 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 0.08 h / 0 °C

4.2: 3 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5.2: 1.5 h / 0 °C / Inert atmosphere

With isopropylmagnesium chloride; sodium hydride; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 459-46-1
4-Fluorobenzyl bromide

: 1373242-31-9
ethyl 2-(3-(6-(benzyloxy)benzo[d][1,3]dioxol-5-yl)-1-(4-fluorobenzyl)-2-oxoindolin-3-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

1.2: 3 h / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 8 h / 0 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 1.5 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 0.08 h / 0 °C

4.2: 3 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5.2: 1.5 h / 0 °C / Inert atmosphere

With isopropylmagnesium chloride; sodium hydride; caesium carbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;