(2-methoxy-6-methylpyridin-4-yl)boronic acid

Base Information

• Chemical Name: (2-methoxy-6-methylpyridin-4-yl)boronic acid
• CAS No.: 1309443-98-8
• Molecular Formula: C₇H₁₀BNO₃
• Molecular Weight: 166.972
• Mol file: 1309443-98-8.mol

Synonyms:(2-methoxy-6-methylpyridin-4-yl)boronic acid

Chemical Property of (2-methoxy-6-methylpyridin-4-yl)boronic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-Methoxy-6-methyl-4-pyridinyl-boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-Methoxy-6-methyl-4-pyridinyl-boronic Acid is used to prepare morpholinothiazoles as alpha 7 positive allosteric modulators useful in the treatment of diseases.

Technology Process of (2-methoxy-6-methylpyridin-4-yl)boronic acid

There total 2 articles about (2-methoxy-6-methylpyridin-4-yl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-6-methyl-pyridine (63071-03-4) + bis(pinacol)diborane (73183-34-3) → (2-methoxy-6-methylpyridin-4-yl)boronic acid (1309443-98-8)

Guidance literature:

2-methoxy-6-methyl-pyridine; bis(pinacol)diborane; With 4,4'-di-tert-butyl-2,2'-bipyridine; bis(1,5-cyclooctadiene)diiridium(I) dichloride; In octane; at 20 ℃; for 4h; Inert atmosphere; Reflux;

In octane;

Reference yield:

2-methoxy-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1083168-87-9) → (2-methoxy-6-methylpyridin-4-yl)boronic acid (1309443-98-8)

Guidance literature:

at 20 ℃;

Reference yield:

(2-methoxy-6-methylpyridin-4-yl)boronic acid (1309443-98-8) + 3-(5-amino-8-bromo-2-(pyridin-2-ylmethyl)-[1,2,4] triazolo[1,5-c]pyrimidin-7-yl)benzonitrile + trifluoroacetic acid (76-05-1) → 3-(5-amino-8-(2-methoxy-6-methylpyridin-4-yl)-2-(pyridin-2-ylmethyl)[1,2,4]triazolo[1,5-c]pyrimidin-7-yl)benzonitrile trifluoroacetic acid

Guidance literature:

(2-methoxy-6-methylpyridin-4-yl)boronic acid; 3-(5-amino-8-bromo-2-(pyridin-2-ylmethyl)-[1,2,4] triazolo[1,5-c]pyrimidin-7-yl)benzonitrile; With chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); sodium carbonate; In 1,4-dioxane; water; at 100 ℃; for 1h;

trifluoroacetic acid; In water; acetonitrile;

upstream raw materials:

2-methoxy-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

2-methoxy-6-methyl-pyridine

bis(pinacol)diborane

Refernces

• 1、 -. "MORPHOLINOTHIAZOLES AS ALPHA 7 POSITIVE ALLOSTERIC MODULATORS". Page/Page column 30-31. . Retrieved 2011/06/23.