Technology Process of 4-chloro-2,3-difluoro-5-hydroxybenzoicacid
There total 3 articles about 4-chloro-2,3-difluoro-5-hydroxybenzoicacid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-chloro-3,4-difluoro-1-(methoxymethoxy)benzene;
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium;
In
tetrahydrofuran; hexane;
at -75 ℃;
for 2h;
carbon dioxide;
In
tetrahydrofuran; hexane;
With
hydrogenchloride;
pH=1;
DOI:10.1055/s-2004-829110
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 82 percent / N-ethyldiisopropylamine / CH2Cl2 / 2 h / 25 °C
2.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 2 h / -75 °C
2.2: 78 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane
3.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 2 h / -75 °C
3.2: tetrahydrofuran; hexane
3.3: 83 percent / aq. HCl / pH 1
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1055/s-2004-829110
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 2 h / -75 °C
1.2: 78 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; hexane
2.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 2 h / -75 °C
2.2: tetrahydrofuran; hexane
2.3: 83 percent / aq. HCl / pH 1
With
2,2,6,6-tetramethyl-piperidine; n-butyllithium;
In
tetrahydrofuran; hexane;
DOI:10.1055/s-2004-829110
