(2S, 3R, 4S, 5S, 6R)-2-(3-(4-methoxybenzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy-2H-pyran-3,4,5-triol

Base Information

Chemical Name:(2S, 3R, 4S, 5S, 6R)-2-(3-(4-methoxybenzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy-2H-pyran-3,4,5-triol
CAS No.:1210040-47-3
Molecular Formula:C₂₁H₂₅ClO₇
Molecular Weight:424.878
Hs Code.:

Synonyms:(2S, 3R, 4S, 5S, 6R)-2-(3-(4-methoxybenzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy-2H-pyran-3,4,5-triol

Suppliers and Price of (2S, 3R, 4S, 5S, 6R)-2-(3-(4-methoxybenzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy-2H-pyran-3,4,5-triol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (2S, 3R, 4S, 5S, 6R)-2-(3-(4-methoxybenzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy-2H-pyran-3,4,5-triol

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (2S, 3R, 4S, 5S, 6R)-2-(3-(4-methoxybenzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy-2H-pyran-3,4,5-triol

There total 5 articles about (2S, 3R, 4S, 5S, 6R)-2-(3-(4-methoxybenzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy-2H-pyran-3,4,5-triol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 333361-51-6
4-bromo-1-chloro-2-(4-methoxybenzyl)benzene

: 75-75-2,98527-29-8
methanesulfonic acid

: 32469-28-6,55515-28-1,55515-29-2,32384-65-9
(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

: 1210040-47-3
(2S, 3R, 4S, 5S, 6R)-2-(3-(4-methoxybenzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy-2H-pyran-3,4,5-triol

Guidance literature:: 4-bromo-1-chloro-2-(4-methoxybenzyl)benzene; (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one; With n-butyllithium; In tetrahydrofuran; at -75 - 30 ℃; for 3.33333h; Inert atmosphere;

methanesulfonic acid; In tetrahydrofuran; methanol; at -75 - 30 ℃; for 16h; Inert atmosphere;

Reference yield:

: 67-56-1
methanol

: 333361-51-6
4-bromo-1-chloro-2-(4-methoxybenzyl)benzene

: 32469-28-6,55515-28-1,55515-29-2,32384-65-9
(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one

: 1210040-47-3
(2S, 3R, 4S, 5S, 6R)-2-(3-(4-methoxybenzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy-2H-pyran-3,4,5-triol

Guidance literature:: 4-bromo-1-chloro-2-(4-methoxybenzyl)benzene; With n-butyllithium; In tetrahydrofuran; hexane; toluene; at -78 - -70 ℃; Inert atmosphere;

(3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one; In tetrahydrofuran; hexane; toluene; at -78 - -70 ℃; Inert atmosphere;

methanol; With hydrogenchloride; water; In tetrahydrofuran; hexane; toluene; at -45 - 20 ℃;

Reference yield:

: 21739-92-4
5-bromo-2-chlorobenzoic acid

: 1210040-47-3
(2S, 3R, 4S, 5S, 6R)-2-(3-(4-methoxybenzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy-2H-pyran-3,4,5-triol

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 5 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 6 h / 0 - 30 °C

3.1: titanium tetrachloride; triethylsilane / dichloromethane / 4.25 h / 0 - 30 °C

4.1: n-butyllithium / tetrahydrofuran / 3.33 h / -75 - 30 °C / Inert atmosphere

4.2: 16 h / -75 - 30 °C / Inert atmosphere

With triethylsilane; aluminum (III) chloride; n-butyllithium; oxalyl dichloride; titanium tetrachloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;