(2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonylpropyl)phenyl)-2-propoxy)tetrahydropyran

Base Information

Chemical Name:(2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonylpropyl)phenyl)-2-propoxy)tetrahydropyran
CAS No.:162489-71-6
Molecular Formula:C₃₅H₃₈ClNO₅S
Molecular Weight:620.209
Hs Code.:

Synonyms:(2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonylpropyl)phenyl)-2-propoxy)tetrahydropyran

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Chemical Property of (2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonylpropyl)phenyl)-2-propoxy)tetrahydropyran

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Technology Process of (2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonylpropyl)phenyl)-2-propoxy)tetrahydropyran

There total 2 articles about (2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonylpropyl)phenyl)-2-propoxy)tetrahydropyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.7%

: 869186-47-0
(2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-hydroxypropyl)phenyl)-2-propoxy)tetrahydropyran

: 124-63-0
methanesulfonyl chloride

: 162489-71-6
(2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonylpropyl)phenyl)-2-propoxy)tetrahydropyran

Guidance literature:: With triethylamine; In dichloromethane; at -10 - 0 ℃; for 1.5h;

Reference yield:

: (2-(2-(3-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-oxopropyl)phenyl)-2-propoxy)tetrahydropyran

: 162489-71-6
(2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonylpropyl)phenyl)-2-propoxy)tetrahydropyran

Guidance literature:: Multi-step reaction with 2 steps

1: (-)-diisochlorodiisopinocampheylborane / tetrahydrofuran / 6 h / -15 - 15 °C

2: triethylamine / dichloromethane / 1.5 h / -10 - 0 °C

With (-)-diisochlorodiisopinocampheylborane; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield: 88.0%

: 162489-71-6
(2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonylpropyl)phenyl)-2-propoxy)tetrahydropyran

: 142148-14-9
methyl 1-(acetylthiomethyl)cyclopropylacetic acid

: 1000788-70-4
1-(((1-(R)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-((1-tetrahydropyranyloxy)-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropyl acetate

Guidance literature:: methyl 1-(acetylthiomethyl)cyclopropylacetic acid; With hydrazine; In N,N-dimethyl-formamide; at 0 ℃; for 1.1h; Inert atmosphere;

(2-(2-(3-(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonylpropyl)phenyl)-2-propoxy)tetrahydropyran; With caesium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;