(R)-4-Benzyloxy-3-tert-butoxycarbonylamino-butyric acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:(R)-4-Benzyloxy-3-tert-butoxycarbonylamino-butyric acid 2,2,2-trichloro-ethyl ester
CAS No.:218943-33-0
Molecular Formula:C₁₈H₂₄Cl₃NO₅
Molecular Weight:440.751
Hs Code.:

Synonyms:(R)-4-Benzyloxy-3-tert-butoxycarbonylamino-butyric acid 2,2,2-trichloro-ethyl ester

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Chemical Property of (R)-4-Benzyloxy-3-tert-butoxycarbonylamino-butyric acid 2,2,2-trichloro-ethyl ester

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Technology Process of (R)-4-Benzyloxy-3-tert-butoxycarbonylamino-butyric acid 2,2,2-trichloro-ethyl ester

There total 4 articles about (R)-4-Benzyloxy-3-tert-butoxycarbonylamino-butyric acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 115-20-8
1,1,1-trichloroethanol

: 218943-31-8
(R)-4-(benzyloxy)-3-{[(tert-butoxy)carbonyl]amino}butanoic acid

: 218943-33-0
(R)-4-Benzyloxy-3-tert-butoxycarbonylamino-butyric acid 2,2,2-trichloro-ethyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1039/a805478i

Reference yield:

: 23680-31-1
BOC-O-benzyl-L-serine

: 218943-33-0
(R)-4-Benzyloxy-3-tert-butoxycarbonylamino-butyric acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NEt₃ / tetrahydrofuran / 0.25 h / -25 °C

2: tetrahydrofuran; diethyl ether / 3 h / Ambient temperature

3: 58 percent / H₂O, CF₃CO₂Ag, NEt₃ / tetrahydrofuran / 3 h / -25 - 20 °C

4: 94 percent / DCC, DMAP / CH₂Cl₂ / 16 h / Ambient temperature

With dmap; water; silver trifluoroacetate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1039/a805478i

Reference yield:

: (C₅H₉O₂)(NHCHCOO)(CH₂OC₇H₇)(CO₂C₂H₅)

: 218943-33-0
(R)-4-Benzyloxy-3-tert-butoxycarbonylamino-butyric acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / 3 h / Ambient temperature

2: 58 percent / H₂O, CF₃CO₂Ag, NEt₃ / tetrahydrofuran / 3 h / -25 - 20 °C

3: 94 percent / DCC, DMAP / CH₂Cl₂ / 16 h / Ambient temperature

With dmap; water; silver trifluoroacetate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1039/a805478i