N-((6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzofuran-3-yl)methyl)methanesulfonamide

Base Information

Chemical Name:N-((6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzofuran-3-yl)methyl)methanesulfonamide
CAS No.:1132936-48-1
Molecular Formula:C₂₅H₂₇N₃O₆S
Molecular Weight:497.572
Hs Code.:

Synonyms:N-((6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzofuran-3-yl)methyl)methanesulfonamide

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Chemical Property of N-((6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzofuran-3-yl)methyl)methanesulfonamide

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Technology Process of N-((6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzofuran-3-yl)methyl)methanesulfonamide

There total 5 articles about N-((6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzofuran-3-yl)methyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30186-18-6
4'-bromo-2'-hydroxyacetophenone

: 1132936-48-1
N-((6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzofuran-3-yl)methyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 18.5 h / 25 °C

1.2: 3 h / 25 °C

1.3: 18 h / Reflux

2.1: N-Bromosuccinimide; dibenzoyl peroxide / chlorobenzene / 2 h / Reflux

2.2: 3 h / 70 °C

2.3: 16 h / 80 °C

3.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / toluene; ethanol / 1 h / 100 °C / Microwave irradiation

3.2: 18 h / 25 °C

With N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; sodium carbonate; dibenzoyl peroxide; In ethanol; N,N-dimethyl-formamide; chlorobenzene; toluene;
DOI:10.1016/j.bmcl.2013.04.057

Reference yield:

: 1132943-88-4
N-((6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzofuran-3-yl)methyl)-N-(4-methoxybenzyl)methanesulfonamide

: 1132936-48-1
N-((6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzofuran-3-yl)methyl)methanesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 - 40 ℃; for 20h;

Reference yield:

: 1132940-53-4
1-(3-tert-butyl-5-iodo-4-methoxyphenyl)-2,4-dihydropyrimidine-2,4(1H,3H)-dione

: 1132943-86-2
N-(4-methoxybenzyl)-N-((6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-yl)methyl)methanesulfonamide

: 1132936-48-1
N-((6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)benzofuran-3-yl)methyl)methanesulfonamide

Guidance literature:: 1-(3-tert-butyl-5-iodo-4-methoxyphenyl)-2,4-dihydropyrimidine-2,4(1H,3H)-dione; N-(4-methoxybenzyl)-N-((6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-yl)methyl)methanesulfonamide; With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In ethanol; toluene; at 100 ℃; for 1h; Microwave irradiation;

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 18h;
DOI:10.1016/j.bmcl.2013.04.057