1132940-53-4 Usage
Description
1-(3-tert-Butyl-5-iodo-4-methoxyphenyl)pyrimidin-2,4(1H,3H)-dione is a complex organic compound with a unique molecular structure that features a pyrimidine core, a tert-butyl group, an iodine atom, and a methoxy group attached to a phenyl ring. 1-(3-tert-Butyl-5-iodo-4-Methoxyphenyl)pyriMidin-2,4(1H,3H)-dione is characterized by its potential reactivity and functional groups that can be utilized in various chemical reactions and applications.
Uses
Used in Pharmaceutical Industry:
1-(3-tert-Butyl-5-iodo-4-methoxyphenyl)pyrimidin-2,4(1H,3H)-dione is used as a reactant in the synthesis of aryl uracil inhibitors of hepatitis C virus NS5B polymerase. Its unique structure allows it to serve as a key intermediate in the development of antiviral drugs targeting the replication mechanism of the hepatitis C virus, thereby offering a potential treatment for this infectious disease.
In the synthesis process, the compound's functional groups can be further modified or combined with other molecules to create more complex and effective pharmaceutical agents. The iodine atom, in particular, may facilitate the formation of crucial bonds or contribute to the overall pharmacokinetic properties of the final drug product. The methoxy group can also play a role in modulating the compound's solubility, stability, and interaction with biological targets.
Overall, 1-(3-tert-Butyl-5-iodo-4-methoxyphenyl)pyrimidin-2,4(1H,3H)-dione is a valuable component in the ongoing research and development of novel antiviral therapies, particularly for the treatment of hepatitis C. Its versatile structure and potential reactivity make it a promising candidate for further exploration and application in the pharmaceutical field.
Check Digit Verification of cas no
The CAS Registry Mumber 1132940-53-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,2,9,4 and 0 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1132940-53:
(9*1)+(8*1)+(7*3)+(6*2)+(5*9)+(4*4)+(3*0)+(2*5)+(1*3)=124
124 % 10 = 4
So 1132940-53-4 is a valid CAS Registry Number.
1132940-53-4Relevant articles and documents
Preparation method of dasabuvir key intermediate
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Paragraph 0015; 0046, (2020/08/27)
The invention discloses a preparation method of a dasabuvir key intermediate. The preparation method comprises the following steps: carrying out substitution reaction on a compound A, namely 2-bromobenzonitrile, and a compound B, namely 2-picolinamide, so
Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif
Krueger, A. Chris,Randolph, John T.,Degoey, David A.,Donner, Pamela L.,Flentge, Charles A.,Hutchinson, Douglas K.,Liu, Dachun,Motter, Christopher E.,Rockway, Todd W.,Wagner, Rolf,Beno, David W.A.,Koev, Gennadiy,Lim, Hock B.,Beyer, Jill M.,Mondal, Rubina,Liu, Yaya,Kati, Warren M.,Longenecker, Kenton L.,Molla, Akhteruzzaman,Stewart, Kent D.,Maring, Clarence J.
, p. 3487 - 3490 (2013/07/19)
The synthesis and structure-activity relationships of a novel aryl uracil series which contains a fused 5,6-bicyclic ring unit for HCV NS5B inhibition is described. Several analogs display replicon cell culture potencies in the low nanomolar range along with excellent rat pharmacokinetic values.
PROCESS FOR PREPARING ANTIVIRAL COMPOUND
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Page/Page column 18, (2010/11/04)
This invention is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.
