4-Trifluoromethyl-benzimidic acid methyl ester; hydrochloride

Base Information

• Chemical Name: 4-Trifluoromethyl-benzimidic acid methyl ester; hydrochloride
• CAS No.: 56108-08-8
• Molecular Formula: C₉H₈F₃NO*ClH
• Molecular Weight: 239.625
• Hs Code.: 2924297099
• Mol file: 56108-08-8.mol

Synonyms:4-Trifluoromethyl-benzimidic acid methyl ester; hydrochloride

Chemical Property of 4-Trifluoromethyl-benzimidic acid methyl ester; hydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Methyl 4-(trifluoromethyl)benzimidate hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Trifluoromethyl-benzimidic acid methyl ester; hydrochloride

There total 1 articles about 4-Trifluoromethyl-benzimidic acid methyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + 4-CF3C6H4CN (455-18-5) → 4-Trifluoromethyl-benzimidic acid methyl ester; hydrochloride (56108-08-8)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 - 5 ℃;

DOI:10.1021/jm00008a007

Reference yield:

4-Trifluoromethyl-benzimidic acid methyl ester; hydrochloride (56108-08-8) → 4-(trifluoromethyl)benzimidamide hydrochloride (38980-96-0)

Guidance literature:

With ammonia; In ethanol; at 0 ℃; for 96h;

DOI:10.1021/jm00166a023

Reference yield:

2-Oxo-4-phthalimido-1-butyl acetate (65465-66-9) + 4-Trifluoromethyl-benzimidic acid methyl ester; hydrochloride (56108-08-8) → 2-[2-(4-Trifluoromethyl-phenyl)-1H-imidazol-4-yl]-ethylamine

Guidance literature:

With hydrogenchloride; ammonia; Yield given. Multistep reaction; 1.) a) RT, overnight, b) 60 deg C, 6 h (20 - 25 bar), 2.) reflux;

DOI:10.1021/jm00008a007

upstream raw materials:

methanol

4-CF₃C₆H₄CN

Downstream raw materials:

4-(trifluoromethyl)benzimidamide hydrochloride

Refernces

• 1、 Medwid, Jeffrey B.,Paul, Rolf,Baker, Jannie S.,Brockman, John A.,Du, Mila T.,et al.. "Preparation of Triazolopyrimidines as Potential Antiasthma Agents". . p. 1230 - 1241. Retrieved 2007/10/02.