(5-{3-[tert-butyl(dimethyl)siloxy]propyl}-2-furyl)(4-methoxyphenyl)methanol

Base Information

Chemical Name:(5-{3-[tert-butyl(dimethyl)siloxy]propyl}-2-furyl)(4-methoxyphenyl)methanol
CAS No.:1252814-57-5
Molecular Formula:C₂₁H₃₂O₄Si
Molecular Weight:376.568
Hs Code.:

Synonyms:(5-{3-[tert-butyl(dimethyl)siloxy]propyl}-2-furyl)(4-methoxyphenyl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (5-{3-[tert-butyl(dimethyl)siloxy]propyl}-2-furyl)(4-methoxyphenyl)methanol

Chemical Property:

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Technology Process of (5-{3-[tert-butyl(dimethyl)siloxy]propyl}-2-furyl)(4-methoxyphenyl)methanol

There total 1 articles about (5-{3-[tert-butyl(dimethyl)siloxy]propyl}-2-furyl)(4-methoxyphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 123-11-5
4-methoxy-benzaldehyde

: 112897-35-5
1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-(2-furyl)propane

: 1252814-57-5
(5-{3-[tert-butyl(dimethyl)siloxy]propyl}-2-furyl)(4-methoxyphenyl)methanol

Guidance literature:: 1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-3-(2-furyl)propane; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 0.5h; Inert atmosphere;

4-methoxy-benzaldehyde; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1055/s-0032-1316548

Reference yield: 90.0%

: 1252814-57-5
(5-{3-[tert-butyl(dimethyl)siloxy]propyl}-2-furyl)(4-methoxyphenyl)methanol

: 74-88-4
methyl iodide

: 1252814-58-6
tert-butyl(3-{5-[methoxy(4-methoxyphenyl)methyl]-2-furyl}propoxy)dimethylsilane

Guidance literature:: (5-{3-[tert-butyl(dimethyl)siloxy]propyl}-2-furyl)(4-methoxyphenyl)methanol; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

methyl iodide; In tetrahydrofuran; for 1h;
DOI:10.1055/s-0032-1316548

Reference yield:

: 1252814-57-5
(5-{3-[tert-butyl(dimethyl)siloxy]propyl}-2-furyl)(4-methoxyphenyl)methanol

: 1252814-59-7
C₁₆H₁₈O₄

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

1.2: 1 h

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide; triethylamine / dichloromethane / -78 - 20 °C / Inert atmosphere

With oxalyl dichloride; tetrabutyl ammonium fluoride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 3.1: Swern oxidation;
DOI:10.1055/s-0032-1316548