tert-Butyldimethylsilyl-3-benzyloxymethyl-4-benzyloxy-2-butenol

Base Information

• Chemical Name: tert-Butyldimethylsilyl-3-benzyloxymethyl-4-benzyloxy-2-butenol
• CAS No.: 552879-97-7
• Molecular Formula: C₂₅H₃₆O₃Si
• Molecular Weight: 412.645
• Mol file: 552879-97-7.mol

Synonyms:tert-Butyldimethylsilyl-3-benzyloxymethyl-4-benzyloxy-2-butenol

Chemical Property of tert-Butyldimethylsilyl-3-benzyloxymethyl-4-benzyloxy-2-butenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of tert-Butyldimethylsilyl-3-benzyloxymethyl-4-benzyloxy-2-butenol

There total 1 articles about tert-Butyldimethylsilyl-3-benzyloxymethyl-4-benzyloxy-2-butenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 4-(benzyloxy)-3-<(benzyloxy)methyl>-2-buten-1-ol (107053-41-8) → tert-Butyldimethylsilyl-3-benzyloxymethyl-4-benzyloxy-2-butenol (552879-97-7)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1515/znb-2003-0113

Reference yield: 72.0%

dibromofluoromethane (1868-53-7) + tert-Butyldimethylsilyl-3-benzyloxymethyl-4-benzyloxy-2-butenol (552879-97-7) → 2,2-bis(benzyloxymethyl)-3-bromo-1-tert-butyldimethylsilyloxymethyl-3-fluorocyclopropane (1012785-60-2)

Guidance literature:

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1080/15257770701257210

Reference yield:

Dichlorofluoromethane (75-43-4) + tert-Butyldimethylsilyl-3-benzyloxymethyl-4-benzyloxy-2-butenol (552879-97-7) → (+/-)-tert-Butyldimethylsilyl-[(1SR,3RS)-2,2-bis(benzyloxymethyl)-3-chlor-3-fluorcyclopropyl]methanol + (+/-)-tert-Butyldimethylsilyl-[(1RS,3RS)-2,2-bis(benzyloxymethyl)-3-chlor-3-fluorcyclopropyl]methanol

Guidance literature:

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; In dichloromethane; at 4 ℃; for 48h; Title compound not separated from byproducts;

DOI:10.1515/znb-2003-0113

upstream raw materials:

tert-butyldimethylsilyl chloride

4-(benzyloxy)-3-<(benzyloxy)methyl>-2-buten-1-ol

Downstream raw materials:

2,2-bis(benzyloxymethyl)-3-bromo-1-tert-butyldimethylsilyloxymethyl-3-fluorocyclopropane

2,2-bis(benzyloxymethyl)-3-fluoro-1-methylenecyclopropane

2,2-bis(benzyloxymethyl)-1-bromo-1-bromomethyl-3-fluorocyclopropane

(Z)-9-{[2,2-bis(benzyloxymethyl)-3-fluorocyclopropylidene]methyl}adenine