4-(N-((dimethylamino)methylene)sulfamoyl)benzoyl chloride

Base Information

• Chemical Name: 4-(N-((dimethylamino)methylene)sulfamoyl)benzoyl chloride
• CAS No.: 329076-94-0
• Molecular Formula: C₁₀H₁₁ClN₂O₃S
• Molecular Weight: 274.728
• Mol file: 329076-94-0.mol

Synonyms:4-(N-((dimethylamino)methylene)sulfamoyl)benzoyl chloride

Chemical Property of 4-(N-((dimethylamino)methylene)sulfamoyl)benzoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(N-((dimethylamino)methylene)sulfamoyl)benzoyl chloride

There total 2 articles about 4-(N-((dimethylamino)methylene)sulfamoyl)benzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(aminosulfonyl)-benzoic acid (138-41-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-(N-((dimethylamino)methylene)sulfamoyl)benzoyl chloride (329076-94-0)

Guidance literature:

With oxalyl dichloride; In dichloromethane; at 20 - 40 ℃; Heating / reflux;

Reference yield:

oxalyl dichloride (79-37-8) + 4-(aminosulfonyl)-benzoic acid (138-41-0) → 4-(N-((dimethylamino)methylene)sulfamoyl)benzoyl chloride (329076-94-0)

Guidance literature:

In dichloromethane; N,N-dimethyl-formamide;

Reference yield: 50.0%

4-(N-((dimethylamino)methylene)sulfamoyl)benzoyl chloride (329076-94-0) + ethyl 2-(4-fluorophenyl)acetate (587-88-2) → ethyl 3-(4-(N',N'-dimethylaminomethyleneaminosulphonyl)phenyl)-2-(4-fluorophenyl)-3-oxo-propionate (329076-80-4)

Guidance literature:

ethyl 2-(4-fluorophenyl)acetate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.333333h;

4-(N-((dimethylamino)methylene)sulfamoyl)benzoyl chloride; In tetrahydrofuran;

upstream raw materials:

4-(aminosulfonyl)-benzoic acid

N,N-dimethyl-formamide

oxalyl dichloride

Downstream raw materials:

ethyl 3-(4-(N',N'-dimethylaminomethyleneaminosulphonyl)phenyl)-2-(4-fluorophenyl)-3-oxo-propionate