{(S)-3-[4-(4-methoxy-3-methylbenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetonitrile

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Chemical Name:{(S)-3-[4-(4-methoxy-3-methylbenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetonitrile
CAS No.:1417917-76-0
Molecular Formula:C₂₀H₂₅N₃O₃
Molecular Weight:355.437
Hs Code.:

Synonyms:{(S)-3-[4-(4-methoxy-3-methylbenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetonitrile

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Chemical Property of {(S)-3-[4-(4-methoxy-3-methylbenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetonitrile

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Technology Process of {(S)-3-[4-(4-methoxy-3-methylbenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetonitrile

There total 5 articles about {(S)-3-[4-(4-methoxy-3-methylbenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.2%

: 1417918-16-1
(S)-3-[4-(4-methoxy-3-methylbenzoyl)piperidin-1-yl]pyrrolidin-2-one

: 590-17-0
cyanomethyl bromide

: 1417917-76-0
{(S)-3-[4-(4-methoxy-3-methylbenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetonitrile

Guidance literature:: (S)-3-[4-(4-methoxy-3-methylbenzoyl)piperidin-1-yl]pyrrolidin-2-one; cyanomethyl bromide; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

With chloroacetonitrile; In tetrahydrofuran; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 370864-67-8
4-(methoxy-methyl-carbamoyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1417917-76-0
{(S)-3-[4-(4-methoxy-3-methylbenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / water; dichloromethane / 4 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 13 h / 85 °C

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.2: 0.5 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

: 1417917-64-6
4-(4-methoxy-3-methyl-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester

: 1417917-76-0
{(S)-3-[4-(4-methoxy-3-methylbenzoyl)piperidin-1-yl]-2-oxo-pyrrolidin-1-yl}acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / water; dichloromethane / 4 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 13 h / 85 °C

3.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.2: 0.5 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;