(S)-2-[4-(2,4-Diamino-5,8-dihydro-6H-pyrido[4',3':4,5]furo[2,3-d]pyrimidin-7-ylmethyl)-benzoylamino]-pentanedioic acid diethyl ester

Base Information

Chemical Name:(S)-2-[4-(2,4-Diamino-5,8-dihydro-6H-pyrido[4',3':4,5]furo[2,3-d]pyrimidin-7-ylmethyl)-benzoylamino]-pentanedioic acid diethyl ester
CAS No.:204995-46-0
Molecular Formula:C₂₆H₃₂N₆O₆
Molecular Weight:524.577
Hs Code.:

Synonyms:(S)-2-[4-(2,4-Diamino-5,8-dihydro-6H-pyrido[4',3':4,5]furo[2,3-d]pyrimidin-7-ylmethyl)-benzoylamino]-pentanedioic acid diethyl ester

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Chemical Property of (S)-2-[4-(2,4-Diamino-5,8-dihydro-6H-pyrido[4',3':4,5]furo[2,3-d]pyrimidin-7-ylmethyl)-benzoylamino]-pentanedioic acid diethyl ester

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Technology Process of (S)-2-[4-(2,4-Diamino-5,8-dihydro-6H-pyrido[4',3':4,5]furo[2,3-d]pyrimidin-7-ylmethyl)-benzoylamino]-pentanedioic acid diethyl ester

There total 7 articles about (S)-2-[4-(2,4-Diamino-5,8-dihydro-6H-pyrido[4',3':4,5]furo[2,3-d]pyrimidin-7-ylmethyl)-benzoylamino]-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 133446-60-3
diethyl N-[(4-chloromethyl)benzoyl]-L-glutamate

: 2,4-diamino-5,6,7,8-tetrahydropyrido[4',3':4,5]furo[2,3-d]pyrimidine-7-hydrobromide

: 204995-46-0
(S)-2-[4-(2,4-Diamino-5,8-dihydro-6H-pyrido[4',3':4,5]furo[2,3-d]pyrimidin-7-ylmethyl)-benzoylamino]-pentanedioic acid diethyl ester

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; Ambient temperature;
DOI:10.1021/jm9705420

Reference yield:

: 16450-41-2
L-glutamic acid diethyl ester

: 204995-46-0
(S)-2-[4-(2,4-Diamino-5,8-dihydro-6H-pyrido[4',3':4,5]furo[2,3-d]pyrimidin-7-ylmethyl)-benzoylamino]-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / dimethylformamide / 2 h / 0 °C

2: 47 percent / K₂CO₃ / dimethylsulfoxide / Ambient temperature

With potassium carbonate; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm9705420

Reference yield:

: 1642-81-5
p-(chloromethyl)benzoic acid

: 204995-46-0
(S)-2-[4-(2,4-Diamino-5,8-dihydro-6H-pyrido[4',3':4,5]furo[2,3-d]pyrimidin-7-ylmethyl)-benzoylamino]-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / dimethylformamide / 0.25 h / 0 °C

2: Et₃N / dimethylformamide / 2 h / 0 °C

3: 47 percent / K₂CO₃ / dimethylsulfoxide / Ambient temperature

With potassium carbonate; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm9705420