(R)-8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoic acid

Base Information

Chemical Name:(R)-8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoic acid
CAS No.:1449305-66-1
Molecular Formula:C₂₄H₂₇N₃O₄
Molecular Weight:421.496
Hs Code.:

Synonyms:(R)-8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoic acid

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Chemical Property of (R)-8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoic acid

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Technology Process of (R)-8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoic acid

There total 5 articles about (R)-8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1229611-69-1
(R)-ethyl 8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoate

: 1449305-66-1
(R)-8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 2h;
DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

: 106849-47-2
1,3-dihydro-1-methyl-5-phenyl-3(R,S)-<(benzyloxycarbonyl)-amino>-2H-1,4-benzodiazepin-2-one

: 1449305-66-1
(R)-8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen bromide / acetic acid / 2 h / 20 °C / Inert atmosphere

2: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid

3: benzotriazol-1-ol / chloroform / 18 h / 20 °C

4: sodium hydroxide / methanol; tetrahydrofuran; water / 2 h / 20 °C

With hydrogen bromide; benzotriazol-1-ol; [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; sodium hydroxide; In tetrahydrofuran; methanol; chloroform; water; acetic acid;
DOI:10.1016/j.ejmech.2013.05.017

Reference yield:

: 103421-61-0
3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

: 1449305-66-1
(R)-8-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylamino)-8-oxooctanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid

2: benzotriazol-1-ol / chloroform / 18 h / 20 °C

3: sodium hydroxide / methanol; tetrahydrofuran; water / 2 h / 20 °C

With benzotriazol-1-ol; [(1S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonic acid; sodium hydroxide; In tetrahydrofuran; methanol; chloroform; water;
DOI:10.1016/j.ejmech.2013.05.017