(S)-1-((4S,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-1-ol

Base Information

• Chemical Name: (S)-1-((4S,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-1-ol
• CAS No.: 276882-72-5
• Molecular Formula: C₁₀H₂₀O₄
• Molecular Weight: 204.266
• Mol file: 276882-72-5.mol

Synonyms:(S)-1-((4S,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-1-ol

Chemical Property of (S)-1-((4S,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-((4S,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-1-ol

There total 2 articles about (S)-1-((4S,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2,3-O-isopropylidene-D-erythrose (189996-60-9) + 1-propylmagnesium chloride (2234-82-4) → (S)-1-((4S,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-1-ol (276882-72-5)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/ja020238i

Reference yield:

(3aR,4S,6aS)-2,2-Dimethyl-5,5-diphenyl-4-propyl-tetrahydro-1,3-dioxa-5-sila-pentalene → (S)-1-((4S,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-1-ol (276882-72-5)

Guidance literature:

With tert.-butylhydroperoxide; potassium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/ol026433j

Reference yield: 76.0%

4-chlorobenzoyl chloride (586-75-4) + (S)-1-((4S,5R)-5-Hydroxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-butan-1-ol (276882-72-5) → C24H26Br2O6

Guidance literature:

With pyridine; In dichloromethane;

DOI:10.1021/ja020238i

upstream raw materials:

2,3-O-isopropylidene-D-erythrose

1-propylmagnesium chloride

Downstream raw materials:

(-)-pinolidoxin