((2R,3R,4R)-3-benzoyloxy-4-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

Base Information

Chemical Name:((2R,3R,4R)-3-benzoyloxy-4-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate
CAS No.:914377-19-8
Molecular Formula:C₂₁H₂₁FO₆
Molecular Weight:388.393
Hs Code.:

Synonyms:((2R,3R,4R)-3-benzoyloxy-4-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((2R,3R,4R)-3-benzoyloxy-4-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

Chemical Property:

Purity/Quality:

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Technology Process of ((2R,3R,4R)-3-benzoyloxy-4-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

There total 8 articles about ((2R,3R,4R)-3-benzoyloxy-4-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

: 67-56-1
methanol

: 1187433-84-6
(2R,3R,4R)-4-fluoro-2-(hydroxymethyl)-5-methoxy-4-methyltetrahydrofuran-3-yl benzoate

: 914377-19-8
((2R,3R,4R)-3-benzoyloxy-4-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-5-hydroxy-4-methyltetrahydrofuran-2-yl)methyl benzoate; methanol; With boron trifluoride diethyl etherate; at 20 - 80 ℃; Inert atmosphere;

With water; sodium hydrogencarbonate; In methanol; Inert atmosphere;
DOI:10.1016/j.bmc.2010.07.017

Reference yield:

: 1187433-85-7
(2R,3R,4R)-4-fluoro-2-(hydroxymethyl)-5-methoxy-4-methyl-tetrahydrofuran-3-ol

: 98-88-4
benzoyl chloride

: 914377-19-8
((2R,3R,4R)-3-benzoyloxy-4-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: With pyridine; at 0 - 20 ℃; for 10h;

Reference yield:

: 1824-96-0,1824-97-1,3795-68-4,3795-69-5,4229-54-3,5531-18-0,7473-45-2,13039-63-9,13039-64-0,13039-65-1,13039-67-3,22416-73-5,22861-09-2,25129-51-5,52485-92-4,52689-55-1,52689-56-2,56607-40-0,72880-70-7,79083-42-4,86782-30-1,86782-31-2,89615-03-2,89673-67-6,89707-99-3,102045-32-9,135910-17-7
methyl ribofuranoside

: 914377-19-8
((2R,3R,4R)-3-benzoyloxy-4-fluoro-5-methoxy-4-methyltetrahydrofuran-2-yl)methyl benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

3: tetrahydrofuran; diethyl ether / 1 h / Inert atmosphere

4: diethylamino-sulfur trifluoride / dichloromethane / 3 h / -5 - 20 °C

5: tetrabutyl ammonium fluoride; acetic acid / dichloromethane / 12 h / 20 °C

6: pyridine / 10 h / 0 - 20 °C

With pyridine; diethylamino-sulfur trifluoride; tetrabutyl ammonium fluoride; Dess-Martin periodane; acetic acid; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;