3-{2-[(2-acetylamino-3-phenyl-propionyl)-(3-methyl-butyl)-amino]-3-phenyl-propionylamino}-N-benzyl-2-hydroxy-butyramide

Base Information

Chemical Name:3-{2-[(2-acetylamino-3-phenyl-propionyl)-(3-methyl-butyl)-amino]-3-phenyl-propionylamino}-N-benzyl-2-hydroxy-butyramide
CAS No.:460336-89-4
Molecular Formula:C₃₆H₄₆N₄O₅
Molecular Weight:614.785
Hs Code.:

3-{2-[(2-acetylamino-3-phenyl-propionyl)-(3-methyl-butyl)-amino]-3-phenyl-propionylamino}-<i>N</i>-benzyl-2-hydroxy-butyramide

Synonyms:3-{2-[(2-acetylamino-3-phenyl-propionyl)-(3-methyl-butyl)-amino]-3-phenyl-propionylamino}-N-benzyl-2-hydroxy-butyramide

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Chemical Property of 3-{2-[(2-acetylamino-3-phenyl-propionyl)-(3-methyl-butyl)-amino]-3-phenyl-propionylamino}-N-benzyl-2-hydroxy-butyramide

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Technology Process of 3-{2-[(2-acetylamino-3-phenyl-propionyl)-(3-methyl-butyl)-amino]-3-phenyl-propionylamino}-N-benzyl-2-hydroxy-butyramide

There total 7 articles about 3-{2-[(2-acetylamino-3-phenyl-propionyl)-(3-methyl-butyl)-amino]-3-phenyl-propionylamino}-N-benzyl-2-hydroxy-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.5%

: 107-85-7
1-amino-3-methylbutane

: 2018-61-3
(S)-2-acetylamino-3-phenylpropanoic acid

: 122-78-1
phenylacetaldehyde

: 460048-60-6
formic acid 1-benzylcarbamoyl-2-isocyano-propyl ester

: 460336-89-4
3-{2-[(2-acetylamino-3-phenyl-propionyl)-(3-methyl-butyl)-amino]-3-phenyl-propionylamino}-N-benzyl-2-hydroxy-butyramide

Guidance literature:: In methanol; dichloromethane; at 20 ℃; for 48h;
DOI:10.1055/s-2002-31948

Reference yield:

: 32331-52-5
N-benzyl glyoxylic amide

: 460336-89-4
3-{2-[(2-acetylamino-3-phenyl-propionyl)-(3-methyl-butyl)-amino]-3-phenyl-propionylamino}-N-benzyl-2-hydroxy-butyramide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 29.0 g / KF/Al₂O₃ / 48 h / 20 °C

2.1: H₂; HCOOH / 10 percent Pd/C; P-2 Ni / methanol / 12 h / 20 °C / 3040 Torr

2.2: Zn; aq. NH₄Cl / methanol / 12 h / 20 °C

3.1: 1.68 g / imidazole; DCC; HCOOH / Et₃N / 48 h / 20 °C

4.1: POCl₃; Et₃N / CH₂Cl₂ / 0.5 h

5.1: 44.5 percent / methanol; CH₂Cl₂ / 48 h / 20 °C

With 1H-imidazole; aluminum oxide; potassium fluoride; formic acid; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trichlorophosphate; palladium on activated charcoal; triethylamine; In methanol; dichloromethane; 5.1: Ugi reaction;
DOI:10.1055/s-2002-31948

Reference yield:

: 88393-56-0
(2R,3R)-N¹,N⁴-dibenzyl-2,3-dihydroxysuccinamide

: 460336-89-4
3-{2-[(2-acetylamino-3-phenyl-propionyl)-(3-methyl-butyl)-amino]-3-phenyl-propionylamino}-N-benzyl-2-hydroxy-butyramide

Guidance literature:: Multi-step reaction with 6 steps

1.1: H₅IO₆ / ethanol; diethyl ether / 24 h / 20 °C

2.1: 29.0 g / KF/Al₂O₃ / 48 h / 20 °C

3.1: H₂; HCOOH / 10 percent Pd/C; P-2 Ni / methanol / 12 h / 20 °C / 3040 Torr

3.2: Zn; aq. NH₄Cl / methanol / 12 h / 20 °C

4.1: 1.68 g / imidazole; DCC; HCOOH / Et₃N / 48 h / 20 °C

5.1: POCl₃; Et₃N / CH₂Cl₂ / 0.5 h

6.1: 44.5 percent / methanol; CH₂Cl₂ / 48 h / 20 °C

With 1H-imidazole; aluminum oxide; potassium fluoride; formic acid; hydrogen; periodic acid; triethylamine; dicyclohexyl-carbodiimide; trichlorophosphate; palladium on activated charcoal; triethylamine; In methanol; diethyl ether; ethanol; dichloromethane; 6.1: Ugi reaction;
DOI:10.1055/s-2002-31948