N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-α-methyl-4-methoxyphenylacetamide

Base Information

Chemical Name:N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-α-methyl-4-methoxyphenylacetamide
CAS No.:293743-38-1
Molecular Formula:C₂₀H₂₂F₃NO₃
Molecular Weight:381.395
Hs Code.:

Synonyms:N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-α-methyl-4-methoxyphenylacetamide

Suppliers and Price of N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-α-methyl-4-methoxyphenylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-α-methyl-4-methoxyphenylacetamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-α-methyl-4-methoxyphenylacetamide

There total 5 articles about N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-α-methyl-4-methoxyphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 293743-37-0
N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-methoxyphenylacetamide

: 74-88-4
methyl iodide

: 293743-38-1
N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-α-methyl-4-methoxyphenylacetamide

Guidance literature:: N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-4-methoxyphenylacetamide; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

methyl iodide; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/S0968-0896(00)00075-4

Reference yield:

: 14796-89-5
4-methoxy-N-(triphenylphosphoran-ylidene)-aniline

: 293743-38-1
N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-α-methyl-4-methoxyphenylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 92 percent / benzene / 12 h / Heating

2.1: 64 percent / LiAlH₄ / diethyl ether / 2 h / Heating

3.1: 40 percent / pyridine / benzene / 16 h / 80 °C

4.1: n-BuLi; (i-propyl)2NH / tetrahydrofuran; hexane / 0.33 h / -78 °C

4.2: 83 percent / tetrahydrofuran / 20 °C

With pyridine; lithium aluminium tetrahydride; n-butyllithium; diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; benzene; 1.1: Staudinger reaction / 2.1: Reduction / 3.1: Acylation / 4.1: Metallation / 4.2: Alkylation;
DOI:10.1016/S0968-0896(00)00075-4

Reference yield:

: 117730-46-8
N-(1,1,1-trifluoro-2-propyl)-4-methoxyaniline

: 293743-38-1
N-(4-methoxyphenyl)-N-(1,1,1-trifluoro-2-propyl)-α-methyl-4-methoxyphenylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 40 percent / pyridine / benzene / 16 h / 80 °C

2.1: n-BuLi; (i-propyl)2NH / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.2: 83 percent / tetrahydrofuran / 20 °C

With pyridine; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; benzene; 1.1: Acylation / 2.1: Metallation / 2.2: Alkylation;
DOI:10.1016/S0968-0896(00)00075-4