2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole-3-carbaldehyde

Base Information

Chemical Name:2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole-3-carbaldehyde
CAS No.:1488426-98-7
Molecular Formula:C₂₁H₂₀N₄OS
Molecular Weight:376.482
Hs Code.:

Synonyms:2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole-3-carbaldehyde

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Chemical Property of 2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole-3-carbaldehyde

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Technology Process of 2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole-3-carbaldehyde

There total 9 articles about 2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.01%

: 1488426-96-5
2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 1488426-98-7
2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole-3-carbaldehyde

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; at -5 ℃;

2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole; In N,N-dimethyl-formamide; at 55 ℃; for 1h;
DOI:10.1016/j.ejmech.2013.08.018

Reference yield:

: 56809-86-0
1-methyl-1H-indole-2-carbohydrazide

: 1488426-98-7
2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 3 h / 80 °C

2.1: potassium hydroxide / water / 2 h / 110 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.01 h / 20 °C

3.2: 20 °C

4.1: trichlorophosphate / -5 °C

4.2: 1 h / 55 °C

With potassium carbonate; potassium hydroxide; trichlorophosphate; In ethanol; water; N,N-dimethyl-formamide; 4.1: |Vilsmeier-Haack Formylation / 4.2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.ejmech.2013.08.018

Reference yield:

: 62-53-3
aniline

: 1488426-98-7
2-[5-(isopropylthio)-4-phenyl-4H-1,2,4-triazol-3-yl]-1-methyl-1H-indole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride; sodium nitrite; tin(ll) chloride / -5 - 20 °C

2.1: acetic acid / ethanol / 1 h / 80 °C

3.1: polyphosphoric acid / toluene / 5 h / 100 °C

4.1: sodium hydride / tetrahydrofuran / 0.67 h / 0 °C

5.1: hydrazine hydrate / ethanol / 0.75 h / 80 °C

6.1: ethanol / 3 h / 80 °C

7.1: potassium hydroxide / water / 2 h / 110 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 0.01 h / 20 °C

8.2: 20 °C

9.1: trichlorophosphate / -5 °C

9.2: 1 h / 55 °C

With hydrogenchloride; sodium hydride; potassium carbonate; hydrazine hydrate; acetic acid; tin(ll) chloride; potassium hydroxide; sodium nitrite; trichlorophosphate; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; 9.1: |Vilsmeier-Haack Formylation / 9.2: |Vilsmeier-Haack Formylation;
DOI:10.1016/j.ejmech.2013.08.018