2,2-dimethyl-3-(5-(4-(thiazolo[4,5-c]pyridin-2-ylamino)phenyl)pyrimidin-2-yloxy)propionic acid

Base Information

Chemical Name:2,2-dimethyl-3-(5-(4-(thiazolo[4,5-c]pyridin-2-ylamino)phenyl)pyrimidin-2-yloxy)propionic acid
CAS No.:1431299-93-2
Molecular Formula:C₂₁H₁₉N₅O₃S
Molecular Weight:421.48
Hs Code.:

Synonyms:2,2-dimethyl-3-(5-(4-(thiazolo[4,5-c]pyridin-2-ylamino)phenyl)pyrimidin-2-yloxy)propionic acid

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Chemical Property of 2,2-dimethyl-3-(5-(4-(thiazolo[4,5-c]pyridin-2-ylamino)phenyl)pyrimidin-2-yloxy)propionic acid

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Technology Process of 2,2-dimethyl-3-(5-(4-(thiazolo[4,5-c]pyridin-2-ylamino)phenyl)pyrimidin-2-yloxy)propionic acid

There total 6 articles about 2,2-dimethyl-3-(5-(4-(thiazolo[4,5-c]pyridin-2-ylamino)phenyl)pyrimidin-2-yloxy)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1431300-96-7
2,2-dimethyl-3-(5-(4-(thiazolo[4,5-c]pyridin-2-ylamino)phenyl)pyrimidin-2-yloxy)propionic acid methyl ester

: 1431299-93-2
2,2-dimethyl-3-(5-(4-(thiazolo[4,5-c]pyridin-2-ylamino)phenyl)pyrimidin-2-yloxy)propionic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; at 18 - 25 ℃;

Reference yield:

: 1105044-76-5
3-(5-bromopyrimidin-2-yloxy)-2,2-dimethylpropanoic acid methyl ester

: 1431299-93-2
2,2-dimethyl-3-(5-(4-(thiazolo[4,5-c]pyridin-2-ylamino)phenyl)pyrimidin-2-yloxy)propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / Inert atmosphere; Reflux

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

3: water; sodium hydroxide / ethanol / 18 - 25 °C

With bis-triphenylphosphine-palladium(II) chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; sodium carbonate; sodium hydroxide; In 1,4-dioxane; ethanol; water; 2: |Suzuki Coupling;

Reference yield:

: 65128-66-7
thiazolo[4,5-c]pyridine-2(3H)-thione

: 1431299-93-2
2,2-dimethyl-3-(5-(4-(thiazolo[4,5-c]pyridin-2-ylamino)phenyl)pyrimidin-2-yloxy)propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuryl dichloride / 18 - 25 °C

2: hydrogenchloride / 1,4-dioxane; ethanol / 1 h / 120 °C / Microwave irradiation

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane; water / 1 h / 120 °C / Microwave irradiation

4: water; sodium hydroxide / ethanol / 18 - 25 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sulfuryl dichloride; water; sodium carbonate; sodium hydroxide; In 1,4-dioxane; ethanol; water; 3: |Suzuki Coupling;