65128-66-7

Usage

Uses

Used in Pharmaceutical Industry:
Thiazolo[4,5-c]pyridine-2-thiol is utilized as a key intermediate in the synthesis of various pharmaceuticals, particularly for the development of antifungal and antibacterial drugs. Its unique structure and activity against certain pathogens make it a promising candidate for creating new and effective treatments in the medical field.
Used in Materials Science:
In the realm of materials science, Thiazolo[4,5-c]pyridine-2-thiol has been studied for its potential use in the development of organic semiconductors and optoelectronic devices. Its molecular properties contribute to the advancement of these technologies, offering new possibilities for applications in electronic and photonic devices.
Used in Organic Synthesis:
Thiazolo[4,5-c]pyridine-2-thiol serves as a versatile building block in organic synthesis, enabling the creation of a wide range of chemical compounds with diverse applications. Its unique structure allows for the formation of various molecular architectures, facilitating the development of new chemical entities with potential uses in various industries.

InChI:InChI=1/C6H4N2S2/c9-6-8-4-3-7-2-1-5(4)10-6/h1-3H,(H,8,9)

Upstream product

• 75-15-0 carbon disulfide 
• 13091-23-1 4-chloro-3-nitropyridine 
• 38240-23-2 3-aminopyridine-4(1H)-thione 
• 20511-15-3 3-amino-4-chloropyridine 
• 140-89-6 potassium ethyl xanthogenate 

Downstream Products

• 857970-39-9 3H-thiazolo[4,5-c]pyridin-2-one 
• 65128-67-8 2-(methylthio)thiazolo[4,5-c]pyridine 
• 884860-63-3 2-chlorothiazolo[4,5-c]pyridine 
• 1431300-94-5 N-(4-bromophenyl)thiazolo[4,5-c]pyridin-2-ylamine 
• 1431300-96-7 2,2-dimethyl-3-(5-(4-(thiazolo[4,5-c]pyridin-2-ylamino)phenyl)pyrimidin-2-yloxy)propionic acid methyl ester 
• 1431299-93-2 2,2-dimethyl-3-(5-(4-(thiazolo[4,5-c]pyridin-2-ylamino)phenyl)pyrimidin-2-yloxy)propionic acid 
• 159635-90-2 (6R,7R)-7-{2-[(Z)-(S)-1-Benzhydryloxycarbonyl-ethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(thiazolo[4,5-c]pyridin-2-ylsulfanylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 
• 159635-88-8 (6R,7R)-7-{2-[(Z)-Benzhydryloxycarbonylmethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(thiazolo[4,5-c]pyridin-2-ylsulfanylmethyl)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester 

Relevant academic research and scientific papers

General Entry into o-,o′-Heteroatom-Linked N-(Hetero)aryl-Imidazole Motifs by Gold-Catalysed Formal [3+2]-Dipolar Cycloaddition

A general redox-neutral approach into the o-,o′-heteroatom-linked N-(hetero)aryl-imidazole family of heteroaromatics has been developed. New types of heteroatom substituted carbimidoyl nitrenoids are efficiently realised from robust, bench-stable N-(heteroaryl)-pyridinium-N-aminides by formal gold-catalysed [3+2]-dipolar cycloadditions across ynamides. Broad structural variety and functional group tolerance allows rapid access into diverse functionalised scaffolds, as exemplified by the preparation of 8 different heteroaromatic cores. (Figure presented.).

NOVEL HETEROARYL-AMINO DERIVATIVES

Disclosed is a compound of formula (I), wherein R1, R2, L, Rm and Rn are as defined herein. The compound of formula (I) may be used in preventing and/or treating acyl CoA-diacylglycerol acyltransferase 1(DGAT-1) related diseases, such as obesity, coronary disease, hypertension, hyperlipidemia, arteriosclerosis, type II diabetes, stroke, hepatitis C, and the like.

COMPOUNDS FOR MODULATING TRPV3 FUNCTION

The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.

Non-imidazole histamine H3 ligands. Part III. New 4-n-propylpiperazines as non-imidazole histamine H3-antagonists

In search for a new lead of non-imidazole histamine H3-receptor antagonists, a series of 1[(2-thiazolopyridine)-4-n-propyl]piperazines, the analogous 1-[(2-oxazolopyridine)-4-npropyl]piperazines, 1-[(2-benzothiazole)-4- n-propyl]piperazine and 1-[(2-benzooxazole)4-n-propyl]piperazine were prepared and in vitro tested as H3-receptor antagonists (the electrically evoked contraction of the guinea-pig jejunum). It appeared that by comparison of homologous pairs the thiazolo derivatives have slightly higher activity than their oxazolo analogues. The most potent compound of these series is the 1-(2-thiazolo[4,5-c]pyridine)-4-n-propylpiperazine (3c) with pA2 = 7.25 (its oxazole analogue (4g) showed pA2 = 6.9). The structure-activity relationships for compounds with various positions of the nitrogen in the benzene ring for the thiazoles compared with oxazoles are discussed.

β-lactam compounds and process for producing the same

Novel β-lactam compound of the formula [1]: wherein R1is lower alkyl or hydroxy-substituted lower alkyl, R2is H or lower alkyl, X is O or, S, R3is H, metal or protecting group, W is a 6- or 7-membered nitrogen-containing heterocycle optionally being substituted at carbon atoms. Said β-lactam compound shows excellent antibacterial activity against Gram-positive bacteria, particularly against methicillin-resistantStaphylococcus aureusand methicillin-resistant and coagulase-negativeStaphylococcus aureus.

Cephalosporin derivatives

A cephalosporin derivative having a quaternary salt type substituent group at the 3-position, represented by formula (I): STR1 wherein X is a carbon atom or a nitrogen atom; Y is a sulfur atom, an oxygen atom or a nitrogen atom substituted with a substituted or unsubstituted lower alkyl group; R1 is a hydrogen atom, a lower alkyl group or a substituted lower alkyl group; R2 is a lower alkyl group, a substituted lower alkyl group, a lower alkylene group or a substituted lower alkylene group; and A is an unsaturated six-membered heterocyclic ring containing at least one nitrogen atom, or a pharmaceutically acceptable salt thereof is disclosed. The derivatives have excellent antibacterial activities and can be used as a drug for the treatment of various bacterial infections.