3-(1-(4-chlorobenzyl)-3-methyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid

Base Information

Chemical Name:3-(1-(4-chlorobenzyl)-3-methyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid
CAS No.:125687-06-1
Molecular Formula:C₂₁H₂₂ClNO₂
Molecular Weight:355.864
Hs Code.:

Synonyms:3-(1-(4-chlorobenzyl)-3-methyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid

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Chemical Property of 3-(1-(4-chlorobenzyl)-3-methyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid

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Technology Process of 3-(1-(4-chlorobenzyl)-3-methyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid

There total 8 articles about 3-(1-(4-chlorobenzyl)-3-methyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 125687-07-2
3-[1-(4-Chloro-benzyl)-3-methyl-1H-indol-2-yl]-2,2-dimethyl-propionic acid ethyl ester

: 125687-06-1
3-(1-(4-chlorobenzyl)-3-methyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; Heating;
DOI:10.1021/jo00296a063

Reference yield:

: 15118-53-3
2,2-dimethyl-4-oxohexanoic acid

: 103252-87-5
1-[(4-chlorophenyl)methyl]-1-(phenyl)hydrazine hydrochloride

: 125687-09-4
2,2-Dimethyl-3-(3-methyl-1H-indol-2-yl)-propionic acid

: 42365-43-5
(4-chlorophenyl)methanamine hydrochloride

: 125687-06-1
3-(1-(4-chlorobenzyl)-3-methyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid

Guidance literature:: With trifluoroacetic acid; In tert-butyl alcohol; at 60 - 70 ℃; free hydrazine from hydrochloride and 1 N NaOH in toluene;
DOI:10.1021/jo00296a063

Reference yield:

: 54491-23-5
2,2-dimethyl-4-hydroxyhexanoic acid γ-lactone

: 125687-06-1
3-(1-(4-chlorobenzyl)-3-methyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 5 N NaOH, 2.) NaOCl solution / 2.) RuO₂*2H₂O / 1.) water, 1 h, ambient temperature, 2.) below 10 deg C

2: conc. H₂SO₄ / Heating

3: conc. H₂SO₄ / ethanol / Heating

4: 96 percent / 3 N NaOH / tetrahydrofuran / Heating

With sodium hydroxide; sodium hypochlorite; sulfuric acid; ruthenium(IV) oxide; In tetrahydrofuran; ethanol;
DOI:10.1021/jo00296a063