N-(3-chloro-4-methoxybenzyl)formamide

Base Information

• Chemical Name: N-(3-chloro-4-methoxybenzyl)formamide
• CAS No.: 212576-67-5
• Molecular Formula: C₉H₁₀ClNO₂
• Molecular Weight: 199.637
• Mol file: 212576-67-5.mol

Synonyms:N-(3-chloro-4-methoxybenzyl)formamide

Chemical Property of N-(3-chloro-4-methoxybenzyl)formamide

Chemical Property:

Purity/Quality:

N-(3-CHLORO-4-METHOXYBENZYL)FORMAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-chloro-4-methoxybenzyl)formamide

There total 2 articles about N-(3-chloro-4-methoxybenzyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

3-chloro-4-methoxy-benzaldehyde (4903-09-7) + formamide (77287-34-4,77287-35-5,60100-09-6) → N-(3-chloro-4-methoxybenzyl)formamide (212576-67-5)

Guidance literature:

With formic acid; at 130 ℃; for 6h;

DOI:10.1021/jm970815r

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → N-(3-chloro-4-methoxybenzyl)formamide (212576-67-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / SO₂Cl₂, pyridine / 1.) RT, 0.5 h, 2.) 70 deg C, 4 h

2: 64 percent / HCOOH / 6 h / 130 °C

With pyridine; formic acid; sulfuryl dichloride;

DOI:10.1021/jm970815r

Reference yield: 95.0%

N-(3-chloro-4-methoxybenzyl)formamide (212576-67-5) → (3-chloro-4-methoxyphenyl)methylamine hydrogen chloride (41965-95-1)

Guidance literature:

With hydrogenchloride; for 3h; Heating;

DOI:10.1021/jm970815r

upstream raw materials:

3-chloro-4-methoxy-benzaldehyde

formamide

4-methoxy-benzaldehyde

Downstream raw materials:

(3-chloro-4-methoxyphenyl)methylamine hydrogen chloride

4-(3-Chloro-4-methoxybenzyl)amino-1,6-dichloro-phthalazine

1-Chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanophthalazine

1-Chloro-4-(3-chloro-4-methoxybenzyl)amino-6-nitrophthalazine

Refernces