2-Chloro-1-[4-(2-methoxyphenyl)piperazino]propan-1-one

Base Information

Chemical Name:2-Chloro-1-[4-(2-methoxyphenyl)piperazino]propan-1-one
CAS No.:95395-48-5
Molecular Formula:C14H19 Cl N2 O2
Molecular Weight:282.76586
Hs Code.:2933599090
DSSTox Substance ID:DTXSID80396332
Mol file:95395-48-5.mol

Synonyms:95395-48-5;2-chloro-1-[4-(2-methoxyphenyl)piperazino]propan-1-one;DTXSID80396332;1-(2-CHLOROPROPIONYL)-4-(2-METHOXYPHENYL)PIPERAZINE;2-chloro-1-[4-(2-methoxyphenyl)piperazin-1-yl]propan-1-one;MFCD08060551;AKOS000188488;1-(2-chloropropanyl)-4-(2-methoxyphenyl)piperazine;1-(2-chloro-propionyl)-4-(2-methoxyphenyl)piperazine

Suppliers and Price of 2-Chloro-1-[4-(2-methoxyphenyl)piperazino]propan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-Chloro-1-[4-(2-methoxyphenyl)piperazino]propan-1-one

Chemical Property:

PSA：32.78000
LogP:1.97400
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:282.1135055
Heavy Atom Count:19
Complexity:306

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)N1CCN(CC1)C2=CC=CC=C2OC)Cl

Technology Process of 2-Chloro-1-[4-(2-methoxyphenyl)piperazino]propan-1-one

There total 1 articles about 2-Chloro-1-[4-(2-methoxyphenyl)piperazino]propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 7623-09-8
2-chloropropionyl chloride

: 5464-78-8
1-(2-methoxyphenyl)piperazine hydrochloride

: 95395-48-5
1-(2-chloropropionyl)-4-(2-methoxyphenyl)piperazine

Guidance literature:: With triethylamine; In chloroform; Ambient temperature;
DOI:10.1248/cpb.32.3981

Reference yield: 60.0%

: 95395-48-5
1-(2-chloropropionyl)-4-(2-methoxyphenyl)piperazine

: 80957-68-2
5,6,7,8-tetrahydro-1,6-naphthyridine

: 95395-47-4
6-<2-<4-(2-methoxyphenyl)-1-piperazinyl>-1-methyl-2-oxoethyl>-5,6,7,8-tetrahydro-1,6-naphthyridine

Guidance literature:: With triethylamine; In ethanol; Heating;
DOI:10.1248/cpb.32.3981

Reference yield:

: 95395-48-5
1-(2-chloropropionyl)-4-(2-methoxyphenyl)piperazine

: 84328-17-6
6-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-1-methyl-ethyl}-5,6,7,8-tetrahydro-[1,6]naphthyridine; compound with (2S,3S)-2,3-dihydroxy-succinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / Et₃N / ethanol / Heating

2: LiAlH₄ / 1.) ether, reflux; 2.) acetone

With lithium aluminium tetrahydride; triethylamine; In ethanol;
DOI:10.1248/cpb.32.3981