2,2,2-trichloroethyl 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenylcarbamate

Base Information

Chemical Name:2,2,2-trichloroethyl 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenylcarbamate
CAS No.:1569982-60-0
Molecular Formula:C₂₁H₁₉Cl₃N₄O₄
Molecular Weight:497.765
Hs Code.:

Synonyms:2,2,2-trichloroethyl 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenylcarbamate

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Chemical Property of 2,2,2-trichloroethyl 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenylcarbamate

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Technology Process of 2,2,2-trichloroethyl 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenylcarbamate

There total 6 articles about 2,2,2-trichloroethyl 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1569981-66-3
4-methoxy-N¹-(6-(2-methoxyphenyl)pyrimidin-4-yl)benzene-1,3-diamine

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 1569982-60-0
2,2,2-trichloroethyl 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenylcarbamate

Guidance literature:: With pyridine; at 0 - 20 ℃;

Reference yield:

: 75634-03-6
4-chloro-6-(2-methoxy-phenyl)-pyrimidine

: 1569982-60-0
2,2,2-trichloroethyl 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: tert-butyl alcohol / 6 h / Reflux

2: triethylamine; palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 20 °C

3: pyridine / 0 - 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane; tert-butyl alcohol;

Reference yield:

: 5720-06-9
2-Methoxyphenylboronic acid

: 1569982-60-0
2,2,2-trichloroethyl 2-methoxy-5-(6-(2-methoxyphenyl)pyrimidin-4-ylamino)phenylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / Inert atmosphere; Reflux

2: tert-butyl alcohol / 6 h / Reflux

3: triethylamine; palladium 10% on activated carbon; hydrogen / methanol; dichloromethane / 20 °C

4: pyridine / 0 - 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; triethylamine; In methanol; 1,2-dimethoxyethane; dichloromethane; water; tert-butyl alcohol;