[5-fluoro-3-({2-[(4-fluorobenzene)sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]acetic acid

Base Information

Chemical Name:[5-fluoro-3-({2-[(4-fluorobenzene)sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]acetic acid
CAS No.:1155694-18-0
Molecular Formula:C₂₃H₁₈F₂N₂O₄S
Molecular Weight:456.47
Hs Code.:

Synonyms:[5-fluoro-3-({2-[(4-fluorobenzene)sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]acetic acid

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Chemical Property of [5-fluoro-3-({2-[(4-fluorobenzene)sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]acetic acid

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Technology Process of [5-fluoro-3-({2-[(4-fluorobenzene)sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]acetic acid

There total 3 articles about [5-fluoro-3-({2-[(4-fluorobenzene)sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1173199-23-9
[5-fluoro-3-({2-[(4-fluorobenzene)sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]-acetic acid ethyl ester

: 1155694-18-0
[5-fluoro-3-({2-[(4-fluorobenzene)sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]acetic acid

Guidance literature:: [5-fluoro-3-({2-[(4-fluorobenzene)sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]-acetic acid ethyl ester; With potassium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=1.5;

Reference yield:

: 824-80-6
sodium 4-fluorobenzenesulfinate

: 1155694-18-0
[5-fluoro-3-({2-[(4-fluorobenzene)sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide / 72 h / 100 °C / Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0 °C

2.2: 15 h / 0 °C

3.1: water; potassium hydroxide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; water; potassium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 36404-88-3
2-chloro-3-carbaldehydepyridine

: 1155694-18-0
[5-fluoro-3-({2-[(4-fluorobenzene)sulfonyl]pyridin-3-yl}methyl)-2-methylindol-1-yl]acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide / 72 h / 100 °C / Inert atmosphere

2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 0 °C

2.2: 15 h / 0 °C

3.1: water; potassium hydroxide / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With trimethylsilyl trifluoromethanesulfonate; water; potassium hydroxide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;