6-NITRO-1-PHENYL-1H-INDAZOLE

Base Information

• Chemical Name: 6-NITRO-1-PHENYL-1H-INDAZOLE
• CAS No.: 91178-59-5
• Molecular Formula: C13H9 N3 O2
• Molecular Weight: 239.22946
• Hs Code.: 2933990090
• Mol file: 91178-59-5.mol

Synonyms:6-NITRO-1-PHENYL-1H-INDAZOLE

Chemical Property of 6-NITRO-1-PHENYL-1H-INDAZOLE

Chemical Property:

• PSA: 63.64000
• LogP: 3.45690
• Storage Temp.: 2-8°C

Purity/Quality:

≥95% ^*data from raw suppliers

6-nitro-1-phenyl-1H-indazole 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-NITRO-1-PHENYL-1H-INDAZOLE

There total 6 articles about 6-NITRO-1-PHENYL-1H-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-bromo-4-nitrobenzaldehyde phenylhydrazone → 1-phenyl-6-nitro-1H-indazole (91178-59-5)

Guidance literature:

With potassium phosphate; bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 110 ℃; for 12h;

DOI:10.1021/jo048671t

Reference yield:

2-bromo-4-nitro-benzaldehyde (5274-71-5) → 1-phenyl-6-nitro-1H-indazole (91178-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / methanol / 0.5 h / Heating

2: 55 percent / K₃PO₄; Pd(dba)2; bis[2-(diphenylphosphino)phenyl] ether / toluene / 12 h / 110 °C

With potassium phosphate; bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In methanol; toluene;

DOI:10.1021/jo048671t

Reference yield:

phenylhydrazine (100-63-0) → 1-phenyl-6-nitro-1H-indazole (91178-59-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / methanol / 0.5 h / Heating

2: 55 percent / K₃PO₄; Pd(dba)2; bis[2-(diphenylphosphino)phenyl] ether / toluene / 12 h / 110 °C

With potassium phosphate; bis[2-(diphenylphosphino)phenyl] ether; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In methanol; toluene;

DOI:10.1021/jo048671t

upstream raw materials:

6-nitro-1-phenyl-1H-indazole-3-carboxylic acid

2-bromo-4-nitro-benzaldehyde

phenylhydrazine

Refernces