(S)-methyl 2-[(S)-(1-benzyloxycarbonylamino)propyl]octanoate

Base Information

• Chemical Name: (S)-methyl 2-[(S)-(1-benzyloxycarbonylamino)propyl]octanoate
• CAS No.: 1181218-09-6
• Molecular Formula: C₂₀H₃₁NO₄
• Molecular Weight: 349.47
• Mol file: 1181218-09-6.mol

Synonyms:(S)-methyl 2-[(S)-(1-benzyloxycarbonylamino)propyl]octanoate

Chemical Property of (S)-methyl 2-[(S)-(1-benzyloxycarbonylamino)propyl]octanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 2-[(S)-(1-benzyloxycarbonylamino)propyl]octanoate

There total 3 articles about (S)-methyl 2-[(S)-(1-benzyloxycarbonylamino)propyl]octanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

methanol (67-56-1) + 2-[(1-amino)propyl]octanoic acid + benzyl chloroformate (501-53-1,94274-21-2) → (S)-methyl 2-[(S)-(1-benzyloxycarbonylamino)propyl]octanoate (1181218-09-6)

Guidance literature:

methanol; 2-[(1-amino)propyl]octanoic acid; With thionyl chloride; at 0 ℃; for 16h; Reflux;

benzyl chloroformate; With sodium hydrogencarbonate; In ethyl acetate;

DOI:10.1021/ja904504j

Reference yield: 8.0%

methyl (S)-3-(benzyloxycarbonylamino)pentanoate (1181218-10-9) + 1-Iodohexane (638-45-9) → (S)-methyl 2-[(S)-(1-benzyloxycarbonylamino)propyl]octanoate (1181218-09-6)

Guidance literature:

With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1021/ja904504j

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + (3S)-3-aminopentanoic acid (14389-77-6) → (S)-methyl 2-[(S)-(1-benzyloxycarbonylamino)propyl]octanoate (1181218-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 16 h / 0 °C / Reflux

2: lithium chloride; lithium diisopropyl amide / tetrahydrofuran

With thionyl chloride; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1021/ja904504j

upstream raw materials:

methyl (S)-3-(benzyloxycarbonylamino)pentanoate

1-Iodohexane

methanol

benzyl chloroformate

Refernces