N-{1-[4-(piperidine-1-sulfonyl)phenyl]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Base Information

Chemical Name:N-{1-[4-(piperidine-1-sulfonyl)phenyl]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
CAS No.:1362132-39-5
Molecular Formula:C₂₁H₂₄N₄O₃S
Molecular Weight:412.513
Hs Code.:

Synonyms:N-{1-[4-(piperidine-1-sulfonyl)phenyl]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

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Chemical Property of N-{1-[4-(piperidine-1-sulfonyl)phenyl]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

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Technology Process of N-{1-[4-(piperidine-1-sulfonyl)phenyl]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

There total 6 articles about N-{1-[4-(piperidine-1-sulfonyl)phenyl]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 800401-65-4
1H-pyrrolo [3,2-c] pyridine-2-carboxylic acid

: 1448536-68-2
1-(4-(piperidin-1-ylsulfonyl)phenyl)ethanamine hydrochloride

: 1362132-39-5
N-{1-[4-(piperidine-1-sulfonyl)phenyl]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: 1H-pyrrolo [3,2-c] pyridine-2-carboxylic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃; for 0.416667h;

1-(4-(piperidin-1-ylsulfonyl)phenyl)ethanamine hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 16h;
DOI:10.1021/jm4008664

Reference yield:

: 85822-16-8
4-formylbenzene-1-sulfonyl chloride

: 1362132-39-5
N-{1-[4-(piperidine-1-sulfonyl)phenyl]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 25 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 2 h / 25 °C / Inert atmosphere

3.1: tetrahydrofuran; diethyl ether / 17 h / -78 - 25 °C

4.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 25 °C

5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.42 h / 25 °C

5.2: 16 h / 25 °C

With hydrogenchloride; titanium(IV) tetraethanolate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm4008664

Reference yield:

: (E)-2-methyl-N-(4-(piperidin-1-ylsulfonyl)benzylidene)propane-2-sulfinamide

: 1362132-39-5
N-{1-[4-(piperidine-1-sulfonyl)phenyl]ethyl}-1H-pyrrolo[3,2-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; diethyl ether / 17 h / -78 - 25 °C

2.1: hydrogenchloride / 1,4-dioxane; methanol / 0.5 h / 25 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.42 h / 25 °C

3.2: 16 h / 25 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm4008664