acetic-p-methylbenzoic anhydride

Base Information

• Chemical Name: acetic-p-methylbenzoic anhydride
• CAS No.: 75474-00-9
• Molecular Formula: C₁₀H₁₀O₃
• Molecular Weight: 178.188
• Mol file: 75474-00-9.mol

Synonyms:acetic-p-methylbenzoic anhydride

Chemical Property of acetic-p-methylbenzoic anhydride

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of acetic-p-methylbenzoic anhydride

There total 5 articles about acetic-p-methylbenzoic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

potassium p-methyl benzoate (16518-25-5) + acetyl chloride (75-36-5) → acetic-p-methylbenzoic anhydride (75474-00-9)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; for 0.133333h;

DOI:10.1081/SCC-120001504

Reference yield: 95.0%

potassium acetate (127-08-2) + 4-methyl-benzoyl chloride (874-60-2) → acetic-p-methylbenzoic anhydride (75474-00-9)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; In chloroform; at 20 ℃; for 2h;

Reference yield: 73.0%

4'-methylacetophenon enol acetate (22390-99-4) → acetic-p-methylbenzoic anhydride (75474-00-9)

Guidance literature:

With iron(III) trifluoromethanesulfonate; 2-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)-6-((4R,5R)-1-((4-(tert-butyl)phenyl)sulfonyl)-4,5-diphenylimidazolidin-2-yl)pyridine; oxygen; In 1,2-dichloro-ethane; at 75 ℃; for 16h; under 760.051 Torr; chemoselective reaction; Green chemistry;

DOI:10.1021/jacs.5b03956

upstream raw materials:

Ketene

p-Toluic acid

carbon monoxide

sodium acetate

Downstream raw materials:

ethenyl 4-methylbenzoate

Acetanilid

p-methylbenzoic anhydride

acetic anhydride

Refernces

• 1、 Hajipour,Mazloumi. "An efficient and simple procedure for preparation of esters and anhydrides from acid chlorides in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) under solvent-free conditions". . p. 23 - 30. Retrieved 2007/10/03.
• 2、 Kikukawa, Kiyoshi,Kono, Kiyoshi,Nagira, Kazuhiko,Wada, Fumio,Matsuda, Tsutomu. "Reaction of Diazonium Salts with Transition Metals. 6. Preparation of Mixed Acid Anhydrides from Arenediazonium Salts and Sodium Carboxylates under Palladium(0) Catalysis". . p. 4413 - 4416. Retrieved 2007/10/02.