(2S)-ethyl 3-methyl-2-(((4-nitrophenoxy)(phenoxy)phosphoryl)amino)butanoate

Base Information

Chemical Name:(2S)-ethyl 3-methyl-2-(((4-nitrophenoxy)(phenoxy)phosphoryl)amino)butanoate
CAS No.:1273029-27-8
Molecular Formula:C₁₉H₂₃N₂O₇P
Molecular Weight:422.375
Hs Code.:

Synonyms:(2S)-ethyl 3-methyl-2-(((4-nitrophenoxy)(phenoxy)phosphoryl)amino)butanoate

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Chemical Property of (2S)-ethyl 3-methyl-2-(((4-nitrophenoxy)(phenoxy)phosphoryl)amino)butanoate

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Technology Process of (2S)-ethyl 3-methyl-2-(((4-nitrophenoxy)(phenoxy)phosphoryl)amino)butanoate

There total 2 articles about (2S)-ethyl 3-methyl-2-(((4-nitrophenoxy)(phenoxy)phosphoryl)amino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 17431-03-7
L-valine ethyl ester

: 770-12-7
O-phenyl phosphorodichloridate

: 1273029-27-8
(2S)-ethyl 3-methyl-2-(((4-nitrophenoxy)(phenoxy)phosphoryl)amino)butanoate

Guidance literature:: L-valine ethyl ester; O-phenyl phosphorodichloridate; With triethylamine; In dichloromethane; at 20 ℃; for 1.08333h; Cooling with ice;

4-nitro-phenol; In dichloromethane;
DOI:10.1021/acs.jmedchem.6b01594

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 17609-47-1
L-Valine ethyl ester hydrochloride

: 770-12-7
O-phenyl phosphorodichloridate

: 1273029-27-8
(2S)-ethyl 3-methyl-2-(((4-nitrophenoxy)(phenoxy)phosphoryl)amino)butanoate

Guidance literature:: L-Valine ethyl ester hydrochloride; O-phenyl phosphorodichloridate; In dichloromethane; at -10 ℃; for 0.166667h;

With triethylamine; In dichloromethane; for 1.08333h;

4-nitro-phenol; With triethylamine; In dichloromethane; for 2.08333h;

Reference yield: 43.0%

: 1273029-27-8
(2S)-ethyl 3-methyl-2-(((4-nitrophenoxy)(phenoxy)phosphoryl)amino)butanoate

: 1191237-69-0
(2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile

: (2S)-ethyl 2-(((((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f ][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)-3-methylbutanoate

Guidance literature:: (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile; With tert-butylmagnesium chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.25h; Cooling with ice;

(2S)-ethyl 3-methyl-2-(((4-nitrophenoxy)(phenoxy)phosphoryl)amino)butanoate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 20 ℃;
DOI:10.1021/acs.jmedchem.6b01594