Technology Process of methyl 2-chloro-6-cyclohexylbenzoate
There total 2 articles about methyl 2-chloro-6-cyclohexylbenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 3 h / 90 °C / Inert atmosphere
2: palladium on activated charcoal; hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; hydrogen; sodium carbonate;
In
1,4-dioxane; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 25 °C
1.2: 21 h / 85 °C
2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,4-dioxane / 3 h / 90 °C / Inert atmosphere
3.1: palladium on activated charcoal; hydrogen / ethyl acetate / 4 h / 20 °C / 760.05 Torr
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; palladium on activated charcoal; hydrogen; sodium carbonate;
In
tetrahydrofuran; 1,4-dioxane; water; ethyl acetate;
- Guidance literature:
-
With
water; sodium hydroxide;
In
methanol;
at 80 ℃;
for 48h;
