8-bromo-[1,6]naphthyridine-2-carboxylic acid (2-isopropoxybenzylamide)

Base Information

Chemical Name:8-bromo-[1,6]naphthyridine-2-carboxylic acid (2-isopropoxybenzylamide)
CAS No.:197507-13-4
Molecular Formula:C₁₉H₁₈BrN₃O₂
Molecular Weight:400.275
Hs Code.:

Synonyms:8-bromo-[1,6]naphthyridine-2-carboxylic acid (2-isopropoxybenzylamide)

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Chemical Property of 8-bromo-[1,6]naphthyridine-2-carboxylic acid (2-isopropoxybenzylamide)

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Technology Process of 8-bromo-[1,6]naphthyridine-2-carboxylic acid (2-isopropoxybenzylamide)

There total 5 articles about 8-bromo-[1,6]naphthyridine-2-carboxylic acid (2-isopropoxybenzylamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 227199-51-1
(2-(isopropyloxy)phenyl)methanamine

: 197507-55-4
8-bromo-[1,6]-naphthyridine-2-carboxylic acid

: 197507-13-4
8-bromo-[1,6]naphthyridine-2-carboxylic acid (2-isopropoxybenzylamide)

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm9902483

Reference yield:

: 98400-69-2
N-(4-pyridyl) t-butyl carbamate

: 197507-13-4
8-bromo-[1,6]naphthyridine-2-carboxylic acid (2-isopropoxybenzylamide)

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / tBuLi / tetrahydrofuran / -78 °C

2: 90 percent / TFA / CH₂Cl₂

3: 90 percent / aq. NaOH

4: 59 percent / Br₂ / acetic acid

5: 69 percent / EDC, HOBT / dimethylformamide

With sodium hydroxide; bromine; tert.-butyl lithium; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm9902483

Reference yield:

: 42373-30-8
4-aminonicotinaldehyde

: 197507-13-4
8-bromo-[1,6]naphthyridine-2-carboxylic acid (2-isopropoxybenzylamide)

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / aq. NaOH

2: 59 percent / Br₂ / acetic acid

3: 69 percent / EDC, HOBT / dimethylformamide

With sodium hydroxide; bromine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm9902483