N^α-Boc-ε-benzyl-D-glutamic acid dipropylamide

Base Information

Chemical Name:N^α-Boc-ε-benzyl-D-glutamic acid dipropylamide
CAS No.:117997-80-5
Molecular Formula:C₂₃H₃₆N₂O₅
Molecular Weight:420.549
Hs Code.:

N<sup>α</sup>-Boc-ε-benzyl-D-glutamic acid dipropylamide

Synonyms:N^α-Boc-ε-benzyl-D-glutamic acid dipropylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N^α-Boc-ε-benzyl-D-glutamic acid dipropylamide

Chemical Property:

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Technology Process of N^α-Boc-ε-benzyl-D-glutamic acid dipropylamide

There total 4 articles about N^α-Boc-ε-benzyl-D-glutamic acid dipropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 35793-73-8
N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid

: 142-84-7
di-n-propylamine

: 117997-80-5
N^α-Boc-ε-benzyl-D-glutamic acid dipropylamide

Guidance literature:: With TEA; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane; at 10 ℃;
DOI:10.1002/(SICI)1099-1344(200001)43:1<77::AID-JLCR292>3.0.CO;2-V

Reference yield:

: 6893-26-1,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
D-Glutamic acid

: 117997-80-5
N^α-Boc-ε-benzyl-D-glutamic acid dipropylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 20 percent / HI / 20 °C

2: 85 percent / TEA / dimethylformamide; H₂O / 20 °C

3: 90 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride; TEA / CH₂Cl₂ / 10 °C

With TEA; hydrogen iodide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane; water; N,N-dimethyl-formamide; 1: Esterification / 2: Acylation / 3: amidation;
DOI:10.1002/(SICI)1099-1344(200001)43:1<77::AID-JLCR292>3.0.CO;2-V

Reference yield:

: 2578-33-8,1676-73-9,29456-09-5,25014-27-1
D-glutamic acid-5-benzyl ester

: 117997-80-5
N^α-Boc-ε-benzyl-D-glutamic acid dipropylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / TEA / dimethylformamide; H₂O / 20 °C

2: 90 percent / bis(2-oxo-3-oxazolidinyl)phosphinic chloride; TEA / CH₂Cl₂ / 10 °C

With TEA; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; In dichloromethane; water; N,N-dimethyl-formamide; 1: Acylation / 2: amidation;
DOI:10.1002/(SICI)1099-1344(200001)43:1<77::AID-JLCR292>3.0.CO;2-V