(Z)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-but-2-enoic acid

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Chemical Name:(Z)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-but-2-enoic acid
CAS No.:1089192-70-0
Molecular Formula:C₄₆H₄₅N₃O₆S
Molecular Weight:767.946
Hs Code.:

Synonyms:(Z)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-but-2-enoic acid

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Chemical Property of (Z)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-but-2-enoic acid

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Technology Process of (Z)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-but-2-enoic acid

There total 4 articles about (Z)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-but-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84624-17-9
N-(9-fluorenylmethoxycarbonyl)-D-valine

: 1089192-70-0
(Z)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-but-2-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 0.17 h / 0 - 5 °C

1.2: 0 - 25 °C

2.1: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 11 h / 0 - 30 °C

3.1: lithium hydroxide; water / tetrahydrofuran / 6 h / 0 - 5 °C

3.2: 0.5 h / 0 - 5 °C

With 1,4-diaza-bicyclo[2.2.2]octane; water; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1089192-69-7
(Z)-2-[(S)-2-((R)-2-amino-3-methyl-butyrylamino)-3-tritylsulfanyl-propionylamino]-but-2-enoic acid methyl ester

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1089192-70-0
(Z)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-but-2-enoic acid

Guidance literature:: (Z)-2-[(S)-2-((R)-2-amino-3-methyl-butyrylamino)-3-tritylsulfanyl-propionylamino]-but-2-enoic acid methyl ester; With water; lithium hydroxide; In tetrahydrofuran; at 0 - 5 ℃; for 6h;

(fluorenylmethoxy)carbonyl chloride; With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 - 5 ℃; for 0.5h;

Reference yield:

: C₃₁H₃₅N₃O₄S

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1089192-70-0
(Z)-2-{(S)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-3-tritylsulfanyl-propionylamino}-but-2-enoic acid

Guidance literature:: C₃₁H₃₅N₃O₄S; (fluorenylmethoxy)carbonyl chloride; With sodium hydrogencarbonate; In tetrahydrofuran; water; for 1h;

With hydrogenchloride; In tetrahydrofuran; water; pH=3 - 4;
DOI:10.1021/jo801866z