2-chloro-N-(5-chloropyridin-2-yl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(5-chloropyridin-2-yl)acetamide
• CAS No.: 90931-33-2
• Molecular Formula: C7H6 Cl2 N2 O
• Molecular Weight: 205.043
• Hs Code.: 2933399090
• European Community (EC) Number: 839-245-0
• DSSTox Substance ID: DTXSID70408852
• Wikidata: Q82214461
• Mol file: 90931-33-2.mol

Synonyms:2-chloro-N-(5-chloropyridin-2-yl)acetamide;90931-33-2;2-chloro-N-(5-chloro-2-pyridinyl)acetamide;SCHEMBL2188598;DTXSID70408852;FWIPEIVJWOOWGO-UHFFFAOYSA-N;MFCD00297021;AKOS000268701;LS-01177;2-Cloro-N-(5-chloropyridin-2-yl)acetamide;CS-0246708;2-Chloro-N- (5-chloropyridin-2-yl)acetamide;EN300-34064;2-Chloro-N-(5-chloro-pyridin-2-yl)-acetamide;E86082;AI-204/33869010

Chemical Property of 2-chloro-N-(5-chloropyridin-2-yl)acetamide

Chemical Property:

• Vapor Pressure: 2.88E-06mmHg at 25°C
• Refractive Index: 1.612
• Boiling Point: 389.3°C at 760 mmHg
• Flash Point: 189.2°C
• PSA: 41.99000
• Density: 1.474g/cm³
• LogP: 1.98530
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 203.9857182
• Heavy Atom Count: 12
• Complexity: 166

Purity/Quality:

97% ^*data from raw suppliers

2-chloro-N-(5-chloro-2-pyridinyl)acetamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC=C1Cl)NC(=O)CCl

Technology Process of 2-chloro-N-(5-chloropyridin-2-yl)acetamide

There total 2 articles about 2-chloro-N-(5-chloropyridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-chloro-2-pyridylamine (1072-98-6) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(2-(5-chloro)pyridinyl)acetamide (90931-33-2)

Guidance literature:

With triethylamine; In chloroform; at 0 - 5 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmcl.2015.08.018

Reference yield: 20.0%

→ 2-chloro-N-(2-(5-chloro)pyridinyl)acetamide (90931-33-2)

Guidance literature:

Reference yield: 90.0%

1-(2-Methoxyphenyl)piperazine (35386-24-4) + 2-chloro-N-(2-(5-chloro)pyridinyl)acetamide (90931-33-2) → N-(5-chloro-pyridin-2-yl)-2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-acetamide (885417-41-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 5h;

DOI:10.1016/S0968-0896(03)00225-6

upstream raw materials:

5-chloro-2-pyridylamine

chloroacetyl chloride

Downstream raw materials:

N-(5-chloro-pyridin-2-yl)-2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-acetamide

2-(2-Cyano-5-methoxycarbonylphenoxy)-N-(5-chloropyridin-2-yl)acetamide

2-(4-Methoxycarbonyl-2-cyanophenoxy)-N-(5-chloropyridin-2-yl)acetamide

(2,4-dicyanophenoxy)-N-(5-chloropyridin-2-yl)acetamide