(R)-4-methoxyphenylalanine methyl ester hydrochloride

Base Information

• Chemical Name: (R)-4-methoxyphenylalanine methyl ester hydrochloride
• CAS No.: 70601-64-8
• Molecular Formula: C₁₁H₁₅NO₃*ClH
• Molecular Weight: 245.706
• Mol file: 70601-64-8.mol

Synonyms:(R)-4-methoxyphenylalanine methyl ester hydrochloride

Chemical Property of (R)-4-methoxyphenylalanine methyl ester hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-4-methoxyphenylalanine methyl ester hydrochloride

There total 13 articles about (R)-4-methoxyphenylalanine methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanol (67-56-1) + N-(tert-butoxycarbonyl)-O-methyl-D-tyrosine (68856-96-2) → (R)-4-methoxyphenylalanine methyl ester hydrochloride (70601-64-8)

Guidance literature:

With chloro-trimethyl-silane; at 20 ℃; for 22h;

DOI:10.1021/jo990311w

Reference yield: 63.0%

2-(tert-butoxycarbonylamino)-2-(4-methoxyphenyl)acetic acid (55362-76-0,78306-98-6) + methyl iodide (74-88-4) → O-methyl-tyrosine methyl ester; hydrochloride (7479-01-8,64657-63-2,70601-64-8)

Guidance literature:

2-(tert-butoxycarbonylamino)-2-(4-methoxyphenyl)acetic acid; With potassium carbonate; In N,N-dimethyl-formamide;

methyl iodide; In N,N-dimethyl-formamide;

With hydrogenchloride; In diethyl ether; N,N-dimethyl-formamide;

Reference yield:

(2R)-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionic acid methyl ester (94790-24-6) → (R)-4-methoxyphenylalanine methyl ester hydrochloride (70601-64-8)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 3h;

DOI:10.1016/j.tet.2014.04.045

upstream raw materials:

methanol

O-methyl tyrosine

p-methoxybenzyl chloride

2-amino-3-(4-methoxyphenyl)propionic acid hydrochloride

Downstream raw materials:

DL-2-Amino-1,1,3-tris(4-methoxyphenyl)-1-propanol

2-(p-methoxybenzyl)ethylenediamine

C₁₄H₁₅NO₄

butyl 2-acetylamino-3-(4-methoxyphenyl)propanoate