4-(2-fluoro-5-(4-(methylthio)benzyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

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Chemical Name:4-(2-fluoro-5-(4-(methylthio)benzyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine
CAS No.:1253571-06-0
Molecular Formula:C₃₃H₃₂FN₅O₂S
Molecular Weight:581.714
Hs Code.:

Synonyms:4-(2-fluoro-5-(4-(methylthio)benzyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

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Chemical Property of 4-(2-fluoro-5-(4-(methylthio)benzyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

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Technology Process of 4-(2-fluoro-5-(4-(methylthio)benzyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

There total 5 articles about 4-(2-fluoro-5-(4-(methylthio)benzyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1253569-14-0
4-chloro-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazine-2-amine

: 1253570-07-8
2-fluoro-5-(4-(methylthio)benzyl)pyridin-3-ylboronic acid

: 1253571-06-0
4-(2-fluoro-5-(4-(methylthio)benzyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate; In ethanol; water; at 88 ℃; for 2.75h; Inert atmosphere;
DOI:10.1021/jm300184s

Reference yield:

: 677728-92-6
2-fluoro-5-formylpyridine

: 1253571-06-0
4-(2-fluoro-5-(4-(methylthio)benzyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0.08 h / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

3.1: Triisopropyl borate; 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 3.5 h / -78 - 22 °C / Inert atmosphere

4.1: sodium hydroxide / tetrahydrofuran; water / 22 °C

4.2: pH 5

5.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate / ethanol; water / 2.75 h / 88 °C / Inert atmosphere

With Triisopropyl borate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); 2,2,6,6-tetramethylpiperidinyl-lithium; potassium acetate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; 5.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300184s

Reference yield:

: 1253570-05-6
2-fluoro-5-(4-(methylthio)benzyl)pyridine

: 1253571-06-0
4-(2-fluoro-5-(4-(methylthio)benzyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: Triisopropyl borate; 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 3.5 h / -78 - 22 °C / Inert atmosphere

2.1: sodium hydroxide / tetrahydrofuran; water / 22 °C

2.2: pH 5

3.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate / ethanol; water / 2.75 h / 88 °C / Inert atmosphere

With Triisopropyl borate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); 2,2,6,6-tetramethylpiperidinyl-lithium; potassium acetate; sodium hydroxide; In tetrahydrofuran; ethanol; water; 3.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300184s