N,N-bis(4-methoxybenzyl)-4-(2-(6-methoxypyridin-3-ylamino)-5-(4-(methylsulfonyl)-benzyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

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Chemical Name:N,N-bis(4-methoxybenzyl)-4-(2-(6-methoxypyridin-3-ylamino)-5-(4-(methylsulfonyl)-benzyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine
CAS No.:1253571-08-2
Molecular Formula:C₃₉H₃₉N₇O₅S
Molecular Weight:717.849
Hs Code.:

Synonyms:N,N-bis(4-methoxybenzyl)-4-(2-(6-methoxypyridin-3-ylamino)-5-(4-(methylsulfonyl)-benzyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

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Chemical Property of N,N-bis(4-methoxybenzyl)-4-(2-(6-methoxypyridin-3-ylamino)-5-(4-(methylsulfonyl)-benzyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

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Technology Process of N,N-bis(4-methoxybenzyl)-4-(2-(6-methoxypyridin-3-ylamino)-5-(4-(methylsulfonyl)-benzyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

There total 7 articles about N,N-bis(4-methoxybenzyl)-4-(2-(6-methoxypyridin-3-ylamino)-5-(4-(methylsulfonyl)-benzyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 6628-77-9
6-methoxy-pyridin-3-ylamine

: 1253571-07-1
4-(2-fluoro-5-(4-(methylsulfonyl)benzyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

: 1253571-08-2
N,N-bis(4-methoxybenzyl)-4-(2-(6-methoxypyridin-3-ylamino)-5-(4-(methylsulfonyl)-benzyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1021/jm300184s

Reference yield:

: 677728-92-6
2-fluoro-5-formylpyridine

: 1253571-08-2
N,N-bis(4-methoxybenzyl)-4-(2-(6-methoxypyridin-3-ylamino)-5-(4-(methylsulfonyl)-benzyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0.08 h / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

3.1: Triisopropyl borate; 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 3.5 h / -78 - 22 °C / Inert atmosphere

4.1: sodium hydroxide / tetrahydrofuran; water / 22 °C

4.2: pH 5

5.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate / ethanol; water / 2.75 h / 88 °C / Inert atmosphere

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.58 h / 22 °C / Inert atmosphere; Cooling with ice

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / 0 °C / Inert atmosphere

With Triisopropyl borate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); 2,2,6,6-tetramethylpiperidinyl-lithium; potassium acetate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; water; 5.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300184s

Reference yield:

: 1253571-06-0
4-(2-fluoro-5-(4-(methylthio)benzyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine

: 1253571-08-2
N,N-bis(4-methoxybenzyl)-4-(2-(6-methoxypyridin-3-ylamino)-5-(4-(methylsulfonyl)-benzyl)pyridin-3-yl)-6-methyl-1,3,5-triazin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.58 h / 22 °C / Inert atmosphere; Cooling with ice

2: lithium hexamethyldisilazane / tetrahydrofuran / 0.67 h / 0 °C / Inert atmosphere

With 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm300184s