Technology Process of 4-(2-fluoro-5-(4-(methylsulfonyl)benzyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine
There total 7 articles about 4-(2-fluoro-5-(4-(methylsulfonyl)benzyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 22 ℃;
for 0.583333h;
Inert atmosphere;
Cooling with ice;
DOI:10.1021/jm300184s
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: trifluoroacetic acid / dichloromethane / 0.08 h / Inert atmosphere
2.2: 0.5 h / Inert atmosphere
3.1: Triisopropyl borate; 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 3.5 h / -78 - 22 °C / Inert atmosphere
4.1: sodium hydroxide / tetrahydrofuran; water / 22 °C
4.2: pH 5
5.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate / ethanol; water / 2.75 h / 88 °C / Inert atmosphere
6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.58 h / 22 °C / Inert atmosphere; Cooling with ice
With
Triisopropyl borate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); 2,2,6,6-tetramethylpiperidinyl-lithium; potassium acetate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water;
5.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300184s
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Triisopropyl borate; 2,2,6,6-tetramethylpiperidinyl-lithium / tetrahydrofuran / 3.5 h / -78 - 22 °C / Inert atmosphere
2.1: sodium hydroxide / tetrahydrofuran; water / 22 °C
2.2: pH 5
3.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); potassium acetate / ethanol; water / 2.75 h / 88 °C / Inert atmosphere
4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.58 h / 22 °C / Inert atmosphere; Cooling with ice
With
Triisopropyl borate; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); 2,2,6,6-tetramethylpiperidinyl-lithium; potassium acetate; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water;
3.1: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300184s
