ethyl 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate

Base Information

Chemical Name:ethyl 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate
CAS No.:865300-86-3
Molecular Formula:C₁₈H₁₆ClFN₂O₅
Molecular Weight:394.787
Hs Code.:

Synonyms:ethyl 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate

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Chemical Property of ethyl 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate

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Technology Process of ethyl 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate

There total 11 articles about ethyl 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1080623-43-3
amino-[1-(3-chloro-4-fluorobenzyl)-2-oxopiperidin-(4Z)-ylidene]acetic acid ethyl ester

: 4755-77-5
Ethyl oxalyl chloride

: 865300-86-3
ethyl 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate

Guidance literature:: amino-[1-(3-chloro-4-fluorobenzyl)-2-oxopiperidin-(4Z)-ylidene]acetic acid ethyl ester; Ethyl oxalyl chloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 3.5 ℃; for 0.5h; Large scale;

With 1,4-diaza-bicyclo[2.2.2]octane; lithium bromide; In tetrahydrofuran; at 3.5 - 20 ℃; for 16h; Large scale;
DOI:10.1021/acs.joc.6b01229

Reference yield:

: 1549803-42-0
C₁₆H₁₈ClFN₂O₃

: 4755-77-5
Ethyl oxalyl chloride

: 865300-86-3
ethyl 6-(3-chloro-4-fluorobenzyl)-4-hydroxy-3,5-dioxo-2,3,5,6,7,8-hexahydro-2,6-naphthyridine-1-carboxylate

Guidance literature:: C₁₆H₁₈ClFN₂O₃; Ethyl oxalyl chloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 3.5 ℃; Large scale;

With 1,4-diaza-bicyclo[2.2.2]octane; lithium bromide; In tetrahydrofuran; at 20 ℃; for 16h; Large scale;