morpholine-4-carboxylic acid (4-methoxyphenyl)amide

Base Information

• Chemical Name: morpholine-4-carboxylic acid (4-methoxyphenyl)amide
• CAS No.: 95766-89-5
• Molecular Formula: C₁₂H₁₆N₂O₃
• Molecular Weight: 236.271
• Mol file: 95766-89-5.mol

Synonyms:morpholine-4-carboxylic acid (4-methoxyphenyl)amide

Chemical Property of morpholine-4-carboxylic acid (4-methoxyphenyl)amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of morpholine-4-carboxylic acid (4-methoxyphenyl)amide

There total 11 articles about morpholine-4-carboxylic acid (4-methoxyphenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

morpholine (110-91-8,99108-56-2) + carbon monoxide (201230-82-2) + 4-methoxy-aniline (104-94-9) → morpholine-4-carboxylic acid (4-methoxyphenyl)amide (95766-89-5)

Guidance literature:

With oxygen; potassium iodide; palladium(II) iodide; In 1,2-dimethoxyethane; at 100 ℃; for 15h; under 15200 Torr;

DOI:10.1021/jo0494634

Reference yield: 88.0%

morpholine (110-91-8,99108-56-2) + carbon dioxide (124-38-9,18923-20-1) + 4-methoxy-aniline (104-94-9) → morpholine-4-carboxylic acid (4-methoxyphenyl)amide (95766-89-5)

Guidance literature:

carbon dioxide; 4-methoxy-aniline; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃;

With dimethyl sulfoxide; trifluoroacetic anhydride; In dichloromethane; at -60 ℃;

morpholine; With triethylamine; In dichloromethane; for 0.416667h;

DOI:10.1021/acs.joc.7b02905

Reference yield: 87.0%

morpholine (110-91-8,99108-56-2) + 4-methoxybenzohydroxamic acid (10507-69-4) → morpholine-4-carboxylic acid (4-methoxyphenyl)amide (95766-89-5)

Guidance literature:

4-methoxybenzohydroxamic acid; With 4-methyl-morpholine; dimethylbromosulphonium bromide; In 1,2-dichloro-ethane; at 0 ℃; for 2h; Inert atmosphere;

morpholine; In 1,2-dichloro-ethane; at 0 - 80 ℃;

DOI:10.1016/j.tetlet.2012.03.129

upstream raw materials:

morpholine

4-Methoxyphenyl isocyanate

(E,Z)-3-(4-methoxyphenyl)-5-phenylmethylene-2,4-dioxothiazolidine

2,2,2-trichloro-N-(4-methoxyphenyl)acetamide

Refernces

• 1、 Ren, Yiming,Rousseaux, Sophie A. L.. "Metal-Free Synthesis of Unsymmetrical Ureas and Carbamates from CO2 and Amines via Isocyanate Intermediates". . p. 913 - 920. Retrieved 2018/01/28.
• 2、 Kathiravan, Subban,Nicholls, Ian A.. "Rhodium(iii)-catalysed aerobic synthesis of highly functionalized indoles from N-arylurea under mild conditions through C-H activation". supporting information. p. 14964 - 14967. Retrieved 2014/12/11.